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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
600-401-GZ8 | 100 µg | - | - |
6 - 10 business days* |
684.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Anti-PIAS1 Antibody was affinity purified from monospecific antiserum by immunoaffinity... more
Product information "Anti-PIAS1"
Anti-PIAS1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest reactivity to mouse 92.9% homology for the immunogen sequence. Cross-reactivity from PIAS1 family and other sources has not been determined. Protein function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB. [The UniProt Consortium]
Keywords: | Anti-GBP, Anti-PIAS1, Anti-DDXBP1, EC=2.3.2.-, Anti-Gu-binding protein, Anti-DEAD/H box-binding protein 1, Anti-E3 SUMO-protein ligase PIAS1, Anti-RNA helicase II-binding protein, Anti-E3 SUMO-protein transferase PIAS1 |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 600-401-GZ8 |
Properties
Application: | ELISA, IFM, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | synthetic peptide from the internal region of human PIAS1. |
Format: | Purified |
Database Information
KEGG ID : | K04706 | Matching products |
UniProt ID : | O75925 | Matching products |
Gene ID | GeneID 8554 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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