Proteins and Enzymes

Human transferrin is encoded by the TF gene and is an iron-binding blood plasma glycoprotein that controls the level of free iron in biological fluids. Human transferrin binds iron very tightly but reversibly. Human transferrin is the most important iron pool in mammals. Human transferrin has a molecular weight of...

See also 18-161.

Bovine Serum Albumin (BSA), Fraction V is used for various biochemical applications including ELISA (Enzyme-Linked Immunosorbent Assay), high content screenining assays, western blotting, and immunohistochemistry. BSA as a blocking reagent is particularly useful with casein-sensitive antibodies, such as...

GDP-L-Fucose synthase, encoded by the gene TSTA3, is an NADP(H)-binding protein that catalyzes the final step in the synthesis of GDP-L-fucose from GDP-D-mannose. It converts GDP-4-keto-6-deoxy-D-mannose to GDP-L-fucose via a two-step reaction consisting of epimerization followed by NADPH-dependent reduction....

Ready for use. Recombinant TVMV protease with an N-terminal His-tag for simple removal from the cleavage reaction by immobilization on metal-affinity resins. TVMV protease cleaves the sequence ETVRQS, with cleavage occuring between Q and S residues with high specifity. It is mainly used for removing affinity tags...

The heterochromatin protein 1 (HP1) family, which consists of three isoforms HP1alpha (CBX5), HP1beta (CBX1), and HP1gamma (CBX3) are chromatin-associated proteins involved in gene regulation and heterochromatin formation. CBX proteins have an N-terminal chromodomain, a C-terminal chromoshadow domain (CSD), and a...

CBX2 is a component of the polycomb repressive complex 1 and represses protein expression. The chromodomain regions of CBX2 recognizes histone H3 trimethyl lysine 9 (H3K9me3) or trimethyl lysine 27 (H3K27me3). CBX2 knock-out mice have impaired spleen formation, T cell expansion, and inactivation of the X chromosome,...

Key Features Cayman's L3MBTL1 MBT Domains TR-FRET Assay Kit (Cay-601030) was developed using L3MBTL1 MBT domains (human recombinant, GST-tagged) protein.Bulk sizes available upon request "The malignant brain tumor (MBT) domain is structurally related to chromatin binding domains, such as chromodomains, tudor...

Recognition of epigenetic marks can be mediated by small modular protein units of ~50 amino acids called Plant Homeodomain (PHD) fingers. PHD fingers are zinc binding domains that have a Cys4-His-Cys3 motif and are found in more than 100 nuclear proteins that play a role in regulating chromatin. PHD domains often...

Tudor domains (or tudor-like regions) are small protein structural motifs of ~50 amino acids related to the "Royal Family" of methyl readers, which also includes chromo, malignant brain tumor (MBT), PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in...

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain. These domains function in linking protein complexes to acetylated nucleosomes, thereby controlling chromatin...

Histone H4 is one of four core histone proteins, the others being H3, H2B, and H2A, that are involved in the organization of DNA into chromatin. Histones are subject to a variety of posttranslational modifications, such as methylation, acetylation, and citrullination, that can influence chromatin structure and...