Products from South Bay Bio

South Bay Bio

South Bay Bio is a biotechnology company dedicated to providing HTS related products with a focus on the ubiquitin proteasome system. The company was formed in the San Francisco Bay area to provide support to local biotechnology companies, and is located in the city of San Jose.

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Ubiquitin Activating Enzyme E1 [UBE1] (human) (rec.) (untagged)
Ubiquitin Activating Enzyme E1 [UBE1] (human)...

Item number: SBB-CE0011-C050

UBA1, the canonical ubiquitin E1 activating enzyme is a 118kDa protein, which forms a homodimer in its active state and catalyzes the first step of the ubiquitin conjugation cascade. It activates ubiquitin in an ATP-dependent mechanism where ATP is hydrolyzed to AMP and PPi, a ubiquitin C-terminal adenylate intermediate is formed, then transferred to the E1's active site...
Application: Assays
Host: Insect cells
Reactivity: Human
MW: 118 kD
Purity: >95%
Format: Liquid
274.00€
Review
UbcH5c [UBE2D3] (human) (rec.) (untagged)
UbcH5c [UBE2D3] (human) (rec.) (untagged)

Item number: SBB-CE0019-C100

UBE2D3 [UbcH5c] is an E2 ubiquitin conjugating enzyme. An E1 activating enzyme is required to attach ubiquitin to UBE2D3 via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2D3-Ub thioester. UBE2D3 is capable of associating with numerous known E3 ligases including MDM2, which...
Application: Assays
Host: E.coli
Reactivity: Human
MW: 17 kD
Purity: >95%
Format: Liquid
260.00€
Review
UbcH7 [UBE2L3] (human) (rec.) (untagged)
UbcH7 [UBE2L3] (human) (rec.) (untagged)

Item number: SBB-CE0020-C100

UBE2L3 (UbcH7) is an E2 ubiquitin conjugating enzyme and accepts ubiquitin from an E1 activating enzyme via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2L3-Ub thioester. UBE2L3 transfers active ubiquitin molecules via a final transthiolation reaction to a cysteine residue...
Application: Assays
Host: E.coli
Reactivity: Human
MW: 18 kD
Purity: >95%
Format: Liquid
260.00€
Review
UbcH5a [UBE2D1] (human) (rec.) (untagged)
UbcH5a [UBE2D1] (human) (rec.) (untagged)

Item number: SBB-CE0021-C100

UBE2D1 (UbcH5a) is an E2 ubiquitin conjugating enzyme. An E1 activating enzyme is required to attach ubiquitin to UBE2D1 via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2D1-Ub thioester. UBE2D1 is capable of associating with numerous known E3 ligases which target abnormal...
Application: Assays
Host: E.coli
Reactivity: Human
MW: 17 kD
Purity: >95%
Format: Liquid
260.00€
Review
UbcH1 [UBE2K, E2-25K] (human) (rec.) (His)
UbcH1 [UBE2K, E2-25K] (human) (rec.) (His)

Item number: SBB-CE0022-C100

UBE2K (UbcH1) is an E2 ubiquitin conjugating enzyme. An E1 activating enzyme is required to attach ubiquitin to UBE2K via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2K-Ub thioester. UBE2K is capable of synthesizing K48-linked ubiquitin chains and can do so without an E3...
Application: Assays
Host: E.coli
Reactivity: Human
MW: 22 kD
Purity: >95%
Format: Liquid
260.00€
Review
UbcH5b [UBE2D2] (human) (rec.) (untagged)
UbcH5b [UBE2D2] (human) (rec.) (untagged)

Item number: SBB-CE0027-C100

UBE2D2 (UbcH5b) is an E2 ubiquitin conjugating enzyme. An E1 activating enzyme is required to attach ubiquitin to UBE2D2 via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2D2-Ub thioester. UBE2D2 is capable of associating with numerous known E3 ligases which target abnormal...
Application: Assays
Host: E.coli
Reactivity: Human
MW: 17 kD
Purity: >95%
Format: Liquid
224.00€
Review
UcH-L3 (human) (rec.) (untagged)
UcH-L3 (human) (rec.) (untagged)

Item number: SBB-DE0023-C050

UCHL3 (Ubiquitin C-terminal Hydrolase L3) is a deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. It is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. It plays a role in regulating apical membrane recycling and...
Application: Assays
Host: E.coli
Reactivity: Human
MW: 26 kD
Purity: >95%
Format: Liquid
162.00€
Review
PLpro (SARS Coronavirus) (rec.) (His)
PLpro (SARS Coronavirus) (rec.) (His)

Item number: SBB-DE0024-C050

The severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV PLpro) is involved in the processing of the viral polyprotein. Proteolytic processing of the coronavirus replicase poly-protein is essential for generating a functional virus replication complex. PLpro possesses both deubiquitinating or deISGylating activity and can process Lys48 and Lys63...
Application: Assays
Host: E.coli
Reactivity: Sars-cov
MW: 37 kD
Purity: >95%
Format: Liquid
217.00€
Review
NEDP1 [SENP8] (human) (rec.) (His)
NEDP1 [SENP8] (human) (rec.) (His)

Item number: SBB-DE0025-C050

NEDP1 is a deconjugating enzyme with specificity towards NEDDylated substrates. NEDP1 discriminates between ubiquitinated and NEDDylated targets, despite similar C-terminal regions. NEDP1 is a protease which hydrolyzes the isopeptide bond between the C-terminus of NEDD8 and the respective lysine of the substrate protein to which the NEDD8 is covalently bound. NEDP1 is...
Application: Assays
Host: E.coli
Reactivity: Human
MW: 27 kD
Purity: >95%
Format: Liquid
162.00€
Review
SENP1 (catalytic domain) (human) (rec.) (His)
SENP1 (catalytic domain) (human) (rec.) (His)

Item number: SBB-DE0026-C050

SUMO/Sentrin Specific Peptidase 1 (SENP1) is a member of the SENP family of proteases, which belong to the group of cysteine-­type peptidases. SENP1 is a SUMO-specific enzyme that catalyzes two essential functions. Processing the full-length versions of SUMO1, SUMO2 and SUMO3 into its mature forms and the deconjugation of SUMOylated proteins. SENP1 is expressed in many...
Application: Assays
Host: E.coli
Reactivity: Human
MW: 32 kD
Purity: >95%
Format: Liquid
162.00€
Review
Mdm2 E3 Ligase TR-FRET Kit
Mdm2 E3 Ligase TR-FRET Kit

Item number: SBB-KF0030-KI01

South Bay Bio's MDM2 TR-FRET Ubiquitin Kit provides a fast and sensitive method monitoring ubiquitin conjugation onto GST-MDM2 in solution, resulting from an enzymatic ubiquitin cascade without the need of running and staining an SDS gel. The kit enables continuous TR-FRET detection of ubiquitin chain formation onto MDM2 in a real-time detection setup, or in an end-point...
Application: Enzyme assays
Reactivity: Human
Format: Homog.
746.00€
Review
ITCH E3 Ligase TR-FRET Kit
ITCH E3 Ligase TR-FRET Kit

Item number: SBB-KF0035-KI01

South Bay Bio's ITCH TR-FRET Ubiquitin Kit provides a fast and sensitive method monitoring ubiquitin conjugation onto ITCH in solution, resulting from an enzymatic ubiquitin cascade without the need of running and staining an SDS gel. The kit enables continuous TR-FRET detection of ubiquitin chain formation onto ITCH in a real-time detection setup, or in an end-point...
Application: Enzyme assays
Reactivity: Human
Format: Homog.
746.00€
Review
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