Products from South Bay Bio

South Bay Bio

South Bay Bio is a biotechnology company dedicated to providing HTS related products with a focus on the ubiquitin proteasome system. The company was formed in the San Francisco Bay area to provide support to local biotechnology companies, and is located in the city of San Jose.

More information at: southbaybio.com

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ITCH E3 Ligase TR-FRET Kit
ITCH E3 Ligase TR-FRET Kit

Item number: SBB-KF0035-KI01

South Bay Bio's ITCH TR-FRET Ubiquitin Kit provides a fast and sensitive method monitoring ubiquitin conjugation onto ITCH in solution, resulting from an enzymatic ubiquitin cascade without the need of running and staining an SDS gel. The kit enables continuous TR-FRET detection of ubiquitin chain formation onto...
Keywords: Itch, ITCH, AIP4, NAPP1, EC=2.3.2.26, NFE2-associated polypeptide 1, Atrophin-1-interacting protein 4, E3...
Application: Enzyme assays
Reactivity: Human
847.00€ *
Review
Ubiquitin aldehyde (human) (rec.)
Ubiquitin aldehyde (human) (rec.)

Item number: SBB-PS0031-C050

Ubiquitin is a small (8.5kDa) regulatory protein that has been found in almost all tissues of eukaryotic organisms. The addition of ubiquitin to a substrate protein is called ubiquitination or ubiquitylation. Ubiquitination can affect proteins in many ways: it can signal for their degradation via the proteasome,...
Application: Assays
Reactivity: Human
MW: 9 kD
135.00€ *
Review
20S Proteasome (human) (untagged)
20S Proteasome (human) (untagged)

Item number: SBB-PP0005-C050

The ubiquitin-proteasome pathway is the major proteolytic system in eukaryotic cells, where it catalyzes the selective degradation of short-lived regulatory proteins or the rapid turnover of misfolded proteins. One of the most important proteases in this pathway is the 26S proteasome, an ATP-dependent proteolytic...
Application: Assays
Reactivity: Human
MW: 700 kD
198.00€ *
Review
Ubiquitin (human) (rec.) (untagged)
Ubiquitin (human) (rec.) (untagged)

Item number: SBB-UP0013-M010

Ubiquitin is a 76 amino acid post-translational modifier expressed throughout all tissues in eukaryotic organisms. The many roles of ubiquitin modification include proteasomal degradation, signal transduction, inflammatory response and DNA damage repair. Ubiquitin modification occurs through a pyramidal cascade of...
Keywords: UBB, Ubiquitin B
Application: Assays
Reactivity: Human
MW: 9 kD
84.00€ *
Review
Ubiquitin Activating Enzyme E1 [UBE1] (human) (rec.) (untagged)
Ubiquitin Activating Enzyme E1 [UBE1] (human) (rec.)...

Item number: SBB-CE0011-C050

UBA1, the canonical ubiquitin E1 activating enzyme is a 118kDa protein, which forms a homodimer in its active state and catalyzes the first step of the ubiquitin conjugation cascade. It activates ubiquitin in an ATP-dependent mechanism where ATP is hydrolyzed to AMP and PPi, a ubiquitin C-terminal adenylate...
Keywords: Ubiquitin E1 Enzyme, Ubiquitin-like Modifier-activating Enzyme 1, A1S9T, AMCX1, GXP1, POC20, SMAX2
Application: Assays
Reactivity: Human
MW: 118 kD
270.00€ *
Review
UbcH5a [UBE2D1] (human) (rec.) (untagged)
UbcH5a [UBE2D1] (human) (rec.) (untagged)

Item number: SBB-CE0021-C100

UBE2D1 (UbcH5a) is an E2 ubiquitin conjugating enzyme. An E1 activating enzyme is required to attach ubiquitin to UBE2D1 via an active site cysteine. The mechanism of ubiquitin transfer involves the breaking of a E1-Ub thioester linkage, followed by a reformation of a UBE2D1-Ub thioester. UBE2D1 is capable of...
Keywords: Ubiquitin-conjugating Enzyme H5a, PUBC1, UBC5A, Ubiquitin-protein Ligase D1, p53-regulated Ubiquitin-conjugating Enzyme 1
Application: Assays
Reactivity: Human
MW: 17 kD
255.00€ *
Review
COVID-19 Research
PLpro (SARS Coronavirus) (rec.) (His)
PLpro (SARS Coronavirus) (rec.) (His)

Item number: SBB-DE0024-C050

The severe acute respiratory syndrome coronavirus papain-like protease (SARS-CoV PLpro) is involved in the processing of the viral polyprotein. Proteolytic processing of the coronavirus replicase poly-protein is essential for generating a functional virus replication complex. PLpro possesses both deubiquitinating or...
Keywords: Papain-like Proteinase, SARS Coronavirus Main Proteinase, Non-structural Protein 3, PL2-PRO, Nsp3
Application: Assays
Reactivity: Sars-cov
MW: 37 kD
212.00€ *
Review
Mdm2 E3 Ligase TR-FRET Kit
Mdm2 E3 Ligase TR-FRET Kit

Item number: SBB-KF0030-KI01

South Bay Bio's MDM2 TR-FRET Ubiquitin Kit provides a fast and sensitive method monitoring ubiquitin conjugation onto GST-MDM2 in solution, resulting from an enzymatic ubiquitin cascade without the need of running and staining an SDS gel. The kit enables continuous TR-FRET detection of ubiquitin chain formation onto...
Keywords: MDM2, Hdm2, EC=2.3.2.27, Oncoprotein Mdm2, Double minute 2 protein, p53-binding protein Mdm2, E3 ubiquitin-protein ligase...
Application: Enzyme assays
Reactivity: Human
847.00€ *
Review
Parkin (E3 Ligase) (human) (rec.) (His)
Parkin (E3 Ligase) (human) (rec.) (His)

Item number: SBB-CE0055-C050

Protein. Human Parkin (Accession Nr. O60260) is fused at the N-terminus to a His-tag. Source: Sf9 cells. Liquid. In 50mM Tris-HCl pH 8.0, 200mM sodium chloride, 10% glycerol, 5mM TCEP. Purity: >95% (SDS-PAGE). Parkin (Parkinson juvenile disease protein 2) is a ~52kDa E3 Ligase enzyme protein, encoded by the PARK2...
Keywords: PARK2, E3 Ubiquitin-protein Ligase Parkin, Parkinson Disease Protein 2, PRKN, Parkin, Parkinson disease protein 2, E3...
MW: 52 kD
392.00€ *
Review
20S Immunoproteasome (rat) (untagged)
20S Immunoproteasome (rat) (untagged)

Item number: SBB-PP0046-C050

Protein. Rat 20S Immunoproteasome. Source: Rat Spleen. Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 1mM TCEP. Purity: >95% (SDS-PAGE). The 20S immunoproteasome is structurally similar to constitutive 26S proteasome. The 20S core of immunoproteasome contains two outer rings composed of alpha-subunits, and two...
MW: 700 kD
270.00€ *
Review
20S Proteasome (mouse) (untagged)
20S Proteasome (mouse) (untagged)

Item number: SBB-PP0047-C050

Protein. Mouse 20S Proteasome. Source: Mouse Erythrocytes. Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 1mM TCEP. Purity: >95% (SDS-PAGE). The ubiquitin-proteasome pathway is the major proteolytic system in eukaryotic cells, where it catalyzes the selective degradation of short-lived regulatory proteins or...
MW: 700 kD
198.00€ *
Review
20S Immunoproteasome (mouse) (untagged)
20S Immunoproteasome (mouse) (untagged)

Item number: SBB-PP0083-C050

Protein. Mouse 20S Immunoproteasome. Source: Mouse Spleen. Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 1mM TCEP. Purity: >92% (SDS-PAGE). The 20S immunoproteasome is structurally similar to constitutive 26S proteasome. The 20S core of immunoproteasome contains two outer rings composed of alpha-subunits, and...
MW: 700 kD
270.00€ *
Review
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