Lipids

Lipids are organic small molecules, that are usually hydrophobic or amphiphillic. This group includes fat, fatty acids, waxes, triglycerides, sterols and phospholipids for example. Lipids are the main structural component of biological membranes of all cells. As such bacterial lipid structures and glycolipids can serve as pathogen-associated-molecular-patterns (PAMPs) and are recognized by our immune system. Various lipids of bacterial origin are therefore used as immunostimulants.

Lipids are organic small molecules, that are usually hydrophobic or amphiphillic. This group includes fat, fatty acids, waxes, triglycerides, sterols and phospholipids for example. Lipids are the... read more »
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Lipids

Lipids are organic small molecules, that are usually hydrophobic or amphiphillic. This group includes fat, fatty acids, waxes, triglycerides, sterols and phospholipids for example. Lipids are the main structural component of biological membranes of all cells. As such bacterial lipid structures and glycolipids can serve as pathogen-associated-molecular-patterns (PAMPs) and are recognized by our immune system. Various lipids of bacterial origin are therefore used as immunostimulants.

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Prostaglandin E2
Prostaglandin E2

Item number: Cay14010-1

PGE2 is one of the primary COX products of arachidonic acid (Cay-90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at least four distinct receptors...
Keywords: Dinoprostone, PGE2, 9-oxo-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid
Application: Bioactive lipid assays
CAS 363-24-6
MW: 352.5 D
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Prostaglandin F2alpha
Prostaglandin F2alpha

Item number: Cay16010-5

Prostaglandin F2alpha (PGF2alpha) is a widely distributed PG occurring in many species. It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity. PGF2alpha exerts its receptor mediated physiological activity at 50-100 nM. Maximal ovine...
Keywords: Dinoprost, PGF2alpha, 9alpha,11alpha,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid
Application: Bioactive lipid assays
CAS 551-11-1
MW: 354.5 D
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15-deoxy-Delta12,14-Prostaglandin J2
15-deoxy-Delta12,14-Prostaglandin J2

Item number: Cay18570-1

15-deoxy-Delta12,14-Prostaglandin J2 (15-deoxy-Delta12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARgamma with an EC50 value of 2 µM in a murine chimera system. 15-deoxy-Delta12,14-PGJ2 is more potent than PGD2, Delta12-PGJ2, and PGJ2 in stimulating...
Keywords: 15-deoxy-Delta12,14-PGJ2, 11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid
Application: Bioactive lipid assays
CAS 87893-55-8
MW: 316.4 D
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Prostaglandin E1
Prostaglandin E1

Item number: Cay13010-1

PGE1 is the theoretical cyclooxygenase metabolite of dihomo-gamma-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals. Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human...
Keywords: Alprostadil, PGE1, 9-oxo-11alpha,15S-dihydroxy-prost-13E-en-1-oic acid
Application: Bioactive lipid assays
CAS 745-65-3
MW: 354.5 D
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15-keto Prostaglandin E1
15-keto Prostaglandin E1

Item number: Cay13680-1

15-keto PGE1 is the inactive metabolite of PGE1 produced by 15-hydroxy PGDH. It has greatly diminished biological activity compared to PGE1. Formal Name: 9,15-dioxo-11alpha-hydroxy-prost-13E-en-1-oic acid. CAS Number: 22973-19-9. Synonyms: 15-keto PGE1. Molecular Formula: C20H32O5. Formula Weight: 352.5. Purity:...
Keywords: 15-keto PGE1, 9,15-dioxo-11alpha-hydroxy-prost-13E-en-1-oic acid
Application: Bioactive lipid assays
CAS 22973-19-9
MW: 352.5 D
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(±)11(12)-EET
(±)11(12)-EET

Item number: Cay50511-50

(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Cay-90010) by cytochrome P450 enzymes. A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET. 11(12)-EET...
Keywords: (±)11,12-EpETrE, (±)11,(12)-epoxy-5Z,8Z,14Z-eicosatrienoic acid
Application: Bioactive lipid assays
CAS 123931-40-8
MW: 320.5 D
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Docosahexaenoic Acid
Docosahexaenoic Acid

Item number: Cay90310-50

DHA is an essential fatty acid and the most abundant omega-3 fatty acid in neural tissues, especially in the retina and brain. DHA constitutes as much as 40% of the total PUFA pool in retinal and neuronal membranes. Supplementation of dietary DHA using fish oil inhibits the progression of atherosclerosis and delays...
Keywords: Cervonic Acid, DHA, 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid
Application: Bioactive lipid studies
CAS 6217-54-5
MW: 328.5 D
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Leukotriene B4
Leukotriene B4

Item number: Cay20110-25

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar...
Keywords: LTB4, 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
Application: Bioactive lipid assays
CAS 71160-24-2
MW: 336.5 D
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(±)5(6)-EET
(±)5(6)-EET

Item number: Cay50211-50

5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid (Cay-90010) by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-delta-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior...
Keywords: (±)5,6-EpETrE, (±)5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid
Application: Bioactive lipid assays
CAS 87173-80-6
MW: 320.5 D
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(±)8(9)-EET
(±)8(9)-EET

Item number: Cay50351-50

(±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Cay-90010). (±)8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex. It activates PPARalpha in HEK293 cells when used at a concentration of 1 µM but inhibits NF-kappaB activity induced by...
Keywords: (±)8,9-EpETrE, (±)8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid
Application: Bioactive lipid assays
MW: 320.5 D
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Sphingosine-1-phosphate
Sphingosine-1-phosphate

Item number: Cay62570-1

Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi...
Keywords: S1P (d18:1), Sphingosine-1-Phosphoric Acid, 2S-amino-4E-octadecene-1,3R-diol 1-(dihydrogen phosphate)
Application: Bioactive lipid assays
CAS 26993-30-6
MW: 379.5 D
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Prostaglandin D2
Prostaglandin D2

Item number: Cay12010-1

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is also produced in the brain via...
Keywords: PGD2, 9alpha,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid
Application: Bioactive lipid assays
CAS 41598-07-6
MW: 352.5 D
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