Products from LC Laboratories

LC Laboratories

LC Laboratories from Woburn, Massachusetts is manufacturing small-molecule reagents since 1980. Numerous reagent vendors sell LC Laboratories` top-quality products under their own labels. If you do signal transduction, oncology or other preclinical research, you have probably been relying on LC Labs products, directly or indirectly, from the time you started your research.

More information at: www.lclabs.com

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Temsirolimus
Temsirolimus

Item number: LC-T-8040_10mg

Solubility: Soluble in DMSO at 200 mg/mL, soluble in ethanol at 200 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Temsirolimus, a rapamycin (sirolimus) derivative, also...
Keywords: CCI-779
Application: MTOR inhibitor
CAS 162635-04-3
MW: 1030.29 D
From 80.00€ *
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Forskolin (Colforsin, CAS 66575-29-9), >99%
Forskolin (Colforsin, CAS 66575-29-9), >99%

Item number: LC-F-9929_100mg

Soluble in DMSO at 160 mg/mL, soluble in ethanol at 50 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 25-50 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
Keywords: Coleonol, HL 362, L 75-1362B, NSC 357088, NSC 375489,...
Application: Adenylate cyclase activator
CAS 66575-29-9
MW: 410,5 D
From 87.00€ *
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Idelalisib, Free Base (CAL-101, GS-1101, Zydelig, CAS 870281-82-6), >99%
Idelalisib, Free Base (CAL-101, GS-1101, Zydelig, CAS...

Item number: LC-I-7447_25mg

Soluble in DMSO
Keywords: Idelalisib, GS-1101, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone
Application: Cell permeable PIK3CD inhibitor
CAS 870281-82-6
MW: 415,42 D
From 78.00€ *
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Neratinib, Free Base
Neratinib, Free Base

Item number: LC-N-6404_100mg

Solubility: Soluble in DMSO at 2 mg/mL with warming, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 5-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Neratinib, also known as HKI-272, is considered to...
Keywords: HKI-272
Application: EGFR/ ERBB2 inhibitor
CAS 698387-09-6
MW: 557,04 D
From 62.00€ *
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Enasidenib, Free Base
Enasidenib, Free Base

Item number: LC-E-2121_5mg

Soluble in DMSO. Enasidenib, also known as AG221, is a potent and selective IDH2 mutant enzyme inhibitor. It caused a significant decrease in R(-)-2-hydroxyglutarate in marrow, plasma, and urine and showed a dose-dependent survival benefit in a primary human AML xenograft model carrying the IDH2 R140Q mutation. Wang...
Keywords: AG221
Application: Antineoplastic, Potent, selective IDH2 mutant enzyme inhibitor
CAS 1446502-11-9
MW: 473.38 D
From 72.00€ *
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Osimertinib, Methanesulfonate Salt
Osimertinib, Methanesulfonate Salt

Item number: LC-O-7233_25mg

Soluble in DMSO. This research compound is the methanesulfonate salt form of osimertinib. Osimertinib, also known as AZD9291, is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). EGFR TKIs have been used to treat patients with non-small-cell lung cancer (NSCLC) harboring sensitizing...
Keywords: AZD9291, Mereletinib
Application: Antineoplastic, EGFR tyrosine kinase inhibitor
CAS 1421373-66-1
MW: 595.72 D
From 76.00€ *
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Ibrutinib, Free Base
Ibrutinib, Free Base

Item number: LC-I-3311_100mg

Solubility: Soluble in DMSO at 200 mg/mL, soluble in ethanol at 25 mg/mL with slight warming. Ibrutinib, also known as PCI-32765, is a selective and irreversible inhibitor of the enzyme Bruton's tyrosine kinase (BTK). It inhibited BTK potently, with an IC50 of 0.72 nM in enzymology assays and with an IC50 of 10 nM...
Keywords: CRA-032765, PCI-32765, PCI-32765-00
Application: Selective, irreversible Bruton's tyrosine kinase (BTK) inhibitor
CAS 936563-96-1
MW: 440.5 D
From 74.00€ *
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Cabazitaxel (Jevtana, RPR-116258, Taxoid XRP6258, TXD-258, XRP-6258, CAS 183133-96-2), >99%
Cabazitaxel (Jevtana, RPR-116258, Taxoid XRP6258,...

Item number: LC-C-2581_100mg

Soluble in DMSO at 100 mg/mL, soluble in ethanol at 50 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 1-2 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
Keywords: beta-[[(1,1-dimethylethoxy)carbonyl]amino]-alpha-hydroxy-benzenepropanoic acid,...
Application: Tubulin depolymerization inhibitor
CAS 183133-96-2
MW: 835,93 D
From 78.00€ *
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Vandetanib, Free Base
Vandetanib, Free Base

Item number: LC-V-9402_100mg

Solubility: Soluble in DMSO at 30 mg/mL, soluble in ethanol at 10 mg/mL with warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Vandetanib inhibits VEGFR-dependent tumor...
Keywords: ZD6474
Application: VEGFR / EGFR Kinase inhibitor
CAS 443913-73-3
MW: 475,35 D
From 82.00€ *
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Alectinib, Free Base
Alectinib, Free Base

Item number: LC-A-2300_100mg

Soluble in DMSO.. Alectinib, also known as CH 5424802, is a potent, selective, and orally available ALK inhibitor (IC50 = 1.9 nM) and has weak or no inhibition against 24 other tested protein kinases. It has selective antitumor activity against cancers with ALK gene alterations, including non-small cell lung cancer...
Keywords: CH 5424802
Application: Antineoplastic, Anaplastic lymphoma kinase (ALK) inhibitor
CAS 1256580-46-7
MW: 482.62 D
From 83.00€ *
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Acalabrutinib, Free Base
Acalabrutinib, Free Base

Item number: LC-A-7337_100mg

Soluble in DMSO. Acalabrutinib, also known as ACP-196, is an irreversible Bruton tyrosine kinase (BTK) inhibitor. It binds covalently to Cys481 with improved selectivity and in vivo target coverage. Acalabrutinib inhibited BTK with an IC50 of 3 nM and had improved target specificity over ibrutinib with 323-, 94-,...
Keywords: ACP196, ACP-196
Application: Antineoplastic, Bruton's tyrosine kinase (BTK) inhibitor
CAS 1420477-60-6
MW: 465.51 D
From 72.00€ *
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Baricitinib, Free Base
Baricitinib, Free Base

Item number: LC-B-1600_100mg

Soluble in DMSO. Baricitinib, also known as INCB028050, is a janus kinase (JAK) inhibitor. It potently and selectively inhibited JAK1 and JAK2 kinases with IC50 values of 5.9 nM and 5.7 nM, respectively. It inhibited intracellular signaling of multiple proinflammatory cytokines including IL-6 and IL-23, with IC50...
Keywords: NCB028050, LY3009104
Application: Antiinflammatory, Antirheumatic, Immunosuppressant, Janus kinase (JAK) inhibitor
CAS 1187594-09-7
MW: 371.42 D
From 71.00€ *
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