Products from LC Laboratories
LC Laboratories from Woburn, Massachusetts is manufacturing small-molecule reagents since 1980. Numerous reagent vendors sell LC Laboratories` top-quality products under their own labels. If you do signal transduction, oncology or other preclinical research, you have probably been relying on LC Labs products, directly or indirectly, from the time you started your research.
More information at: www.lclabs.com
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Neratinib, Free Base Item number: LC-N-6404_100mg
Solubility: Soluble in DMSO at 2 mg/mL with warming, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 5-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Neratinib, also known as HKI-272, is considered to...
| Keywords: | HKI-272 |
| Application: | EGFR/ ERBB2 inhibitor |
| CAS | 698387-09-6 |
| MW: | 557,04 D |
From 62.00€ *
Ibrutinib, Free Base Item number: LC-I-3311_100mg
Solubility: Soluble in DMSO at 200 mg/mL, soluble in ethanol at 25 mg/mL with slight warming. Ibrutinib, also known as PCI-32765, is a selective and irreversible inhibitor of the enzyme Bruton's tyrosine kinase (BTK). It inhibited BTK potently, with an IC50 of 0.72 nM in enzymology assays and with an IC50 of 10 nM...
| Keywords: | CRA-032765, PCI-32765, PCI-32765-00 |
| Application: | Selective, irreversible Bruton's tyrosine kinase (BTK) inhibitor |
| CAS | 936563-96-1 |
| MW: | 440.5 D |
From 74.00€ *
Temsirolimus Item number: LC-T-8040_100mg
Solubility: Soluble in DMSO at 200 mg/mL, soluble in ethanol at 200 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Temsirolimus, a rapamycin (sirolimus) derivative, also...
| Keywords: | CCI-779 |
| Application: | Antineoplastic, MTOR inhibitor |
| CAS | 162635-04-3 |
| MW: | 1030.29 D |
From 80.00€ *
Alectinib, Free Base Item number: LC-A-2300_100mg
Soluble in DMSO.. Alectinib, also known as CH 5424802, is a potent, selective, and orally available ALK inhibitor (IC50 = 1.9 nM) and has weak or no inhibition against 24 other tested protein kinases. It has selective antitumor activity against cancers with ALK gene alterations, including non-small cell lung cancer...
| Keywords: | CH 5424802 |
| Application: | Antineoplastic, Anaplastic lymphoma kinase (ALK) inhibitor |
| CAS | 1256580-46-7 |
| MW: | 482.62 D |
From 83.00€ *
Baricitinib, Free Base Item number: LC-B-1600_100mg
Soluble in DMSO. Baricitinib, also known as INCB028050, is a janus kinase (JAK) inhibitor. It potently and selectively inhibited JAK1 and JAK2 kinases with IC50 values of 5.9 nM and 5.7 nM, respectively. It inhibited intracellular signaling of multiple proinflammatory cytokines including IL-6 and IL-23, with IC50...
| Keywords: | NCB028050, LY3009104 |
| Application: | Antiinflammatory, Antirheumatic, Immunosuppressant, Janus kinase (JAK) inhibitor |
| CAS | 1187594-09-7 |
| MW: | 371.42 D |
From 71.00€ *
Brigatinib, Free Base Item number: LC-B-9800_100mg
Soluble in DMSO. Brigatinib, also known as AP26113, inhibited ALK, IGF-1R, and InsR kinases with IC50 values of 0.37 nM, 24.9 nM, and 196 nM, respectively. It blocked the viability of Karpas 299 cells (ALK+) with an IC50 of 29 nM in vitro. It demonstrated efficacy in multiple ALK+ xenografts in mice, including...
| Keywords: | AP26113 |
| Application: | Antineoplastic, Anaplastic lymphoma kinase (ALK) inhibitor |
| CAS | 1197953-54-0 |
| MW: | 584.09 D |
From 71.00€ *
Cobimetinib, Free Base Item number: LC-C-1100_100mg
Soluble in DMSO. Cobimetinib demonstrated a sustained tumor pharmacodynamic response due to longer residence times in tumor tissue than in plasma in mice. Following single doses, cobimetinib inhibited pERK in tumors with IC50 values of 780 nM in WM-266-4 and 520 nM in A375 xenograft mice. Following multiple doses,...
| Keywords: | GDC0973, RG7420, XL518 |
| Application: | Antineoplastic, Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor |
| CAS | 934660-93-2 |
| MW: | 531.31 D |
From 76.00€ *
Imatinib, Free Base Item number: LC-I-5577_10g
Solubility: Soluble in DMSO at 25 mg/mL with slight warming, soluble in ethanol at 5 mg/mL with slight warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 5-20 µM, buffers, serum, or other additives may increase or decrease. This is the free base form of imatinib, please...
| Keywords: | CGP-57148B, STI-571 |
| Application: | Antineoplastic, Tyrosine kinase inhibitor |
| CAS | 152459-95-5 |
| MW: | 493.6 D |
From 82.00€ *
Lenvatinib, Free Base Item number: LC-L-5400_100mg
Soluble in DMSO. Lenvatinib, also known as E7080, is an active inhibitor of multiple receptor tyrosine kinases, with IC50 values of 22 nM (VEGFR1), 4 nM (VEGFR2), 5.2 nM (VEGFR3), 46 nM (FGFR1), 51 nM (PDGFRa), 39 nM (PDGFRb), and 100 nM (KIT). It inhibited SCF- and VEGF-induced angiogenesis of human umbilical vein...
| Keywords: | E7080, ER20349200 |
| Application: | Antineoplastic, Receptor tyrosine kinase inhibitor |
| CAS | 417716-92-8 |
| MW: | 426.85 D |
From 72.00€ *
PLX4720, Free Base Item number: LC-P-8900_100mg
Soluble in DMSO. PLX4720 is a kinase inhibitor with marked selectivity against B-Raf(V600E), with an IC50 of 13 nM. PLX4720 induced cell cycle arrest and apoptosis exclusively in B-Raf(V600E)-positive cells in melanoma models. In B-Raf(V600E)-dependent tumor xenograft models, PLX4720 caused significant tumor growth...
| Keywords: | Raf Kinase Inhibitor V, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide |
| Application: | B-Raf(V600E) inhibitor |
| CAS | 918505-84-7 |
| MW: | 413.83 D |
From 77.00€ *
Trametinib, DMSO Solvate Item number: LC-T-8188_100mg
Soluble in DMSO. This research compound is the DMSO solvate form of trametinib. Trametinib is a selective MEK inhibitor. Trametinib inhibited MEK1/2 kinase activity, prevented Raf-dependent MEK phosphorylation, and produced prolonged p-ERK1/2 inhibition. It blocked the cell growth potently in most tumor lines with...
| Keywords: | GSK1120212, JTP-74057, Trametinib |
| Application: | Antineoplastic, Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor |
| CAS | 1187431-43-1 |
| MW: | 693.53 D |
From 71.00€ *
Pemafibrate, Free Acid Item number: LC-P-5115_100mg
Soluble in DMSO.
| Keywords: | K-877, R-K-13675 |
| Application: | Antihyperlipidemic, Triglyceride synthesis inhibitor, PPAR alpha agonist |
| CAS | 848259-27-8 |
| MW: | 490.55 D |
From 76.00€ *