Products from LC Laboratories
LC Laboratories from Woburn, Massachusetts is manufacturing small-molecule reagents since 1980. Numerous reagent vendors sell LC Laboratories` top-quality products under their own labels. If you do signal transduction, oncology or other preclinical research, you have probably been relying on LC Labs products, directly or indirectly, from the time you started your research.
More information at: www.lclabs.com
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Temsirolimus Item number: LC-T-8040_10mg
Solubility: Soluble in DMSO at 200 mg/mL, soluble in ethanol at 200 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Temsirolimus, a rapamycin (sirolimus) derivative, also...
| Keywords: | CCI-779 |
| Application: | MTOR inhibitor |
| CAS | 162635-04-3 |
| MW: | 1030.29 D |
From 80.00€ *
Forskolin (Colforsin, CAS 66575-29-9), >99% Item number: LC-F-9929_100mg
Soluble in DMSO at 160 mg/mL, soluble in ethanol at 50 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 25-50 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
| Keywords: | Coleonol, HL 362, L 75-1362B, NSC 357088, NSC 375489,... |
| Application: | Adenylate cyclase activator |
| CAS | 66575-29-9 |
| MW: | 410,5 D |
From 87.00€ *
Idelalisib, Free Base (CAL-101, GS-1101, Zydelig, CAS... Item number: LC-I-7447_25mg
Soluble in DMSO
| Keywords: | Idelalisib, GS-1101, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone |
| Application: | Cell permeable PIK3CD inhibitor |
| CAS | 870281-82-6 |
| MW: | 415,42 D |
From 78.00€ *
Neratinib, Free Base Item number: LC-N-6404_100mg
Solubility: Soluble in DMSO at 2 mg/mL with warming, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 5-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Neratinib, also known as HKI-272, is considered to...
| Keywords: | HKI-272 |
| Application: | EGFR/ ERBB2 inhibitor |
| CAS | 698387-09-6 |
| MW: | 557,04 D |
From 62.00€ *
Enasidenib, Free Base Item number: LC-E-2121_5mg
Soluble in DMSO. Enasidenib, also known as AG221, is a potent and selective IDH2 mutant enzyme inhibitor. It caused a significant decrease in R(-)-2-hydroxyglutarate in marrow, plasma, and urine and showed a dose-dependent survival benefit in a primary human AML xenograft model carrying the IDH2 R140Q mutation. Wang...
| Keywords: | AG221 |
| Application: | Antineoplastic, Potent, selective IDH2 mutant enzyme inhibitor |
| CAS | 1446502-11-9 |
| MW: | 473.38 D |
From 72.00€ *
Osimertinib, Methanesulfonate Salt Item number: LC-O-7233_25mg
Soluble in DMSO. This research compound is the methanesulfonate salt form of osimertinib. Osimertinib, also known as AZD9291, is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). EGFR TKIs have been used to treat patients with non-small-cell lung cancer (NSCLC) harboring sensitizing...
| Keywords: | AZD9291, Mereletinib |
| Application: | Antineoplastic, EGFR tyrosine kinase inhibitor |
| CAS | 1421373-66-1 |
| MW: | 595.72 D |
From 76.00€ *
Ibrutinib, Free Base Item number: LC-I-3311_100mg
Solubility: Soluble in DMSO at 200 mg/mL, soluble in ethanol at 25 mg/mL with slight warming. Ibrutinib, also known as PCI-32765, is a selective and irreversible inhibitor of the enzyme Bruton's tyrosine kinase (BTK). It inhibited BTK potently, with an IC50 of 0.72 nM in enzymology assays and with an IC50 of 10 nM...
| Keywords: | CRA-032765, PCI-32765, PCI-32765-00 |
| Application: | Selective, irreversible Bruton's tyrosine kinase (BTK) inhibitor |
| CAS | 936563-96-1 |
| MW: | 440.5 D |
From 74.00€ *
Cabazitaxel (Jevtana, RPR-116258, Taxoid XRP6258,... Item number: LC-C-2581_100mg
Soluble in DMSO at 100 mg/mL, soluble in ethanol at 50 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 1-2 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
| Keywords: | beta-[[(1,1-dimethylethoxy)carbonyl]amino]-alpha-hydroxy-benzenepropanoic acid,... |
| Application: | Tubulin depolymerization inhibitor |
| CAS | 183133-96-2 |
| MW: | 835,93 D |
From 78.00€ *
Vandetanib, Free Base Item number: LC-V-9402_100mg
Solubility: Soluble in DMSO at 30 mg/mL, soluble in ethanol at 10 mg/mL with warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Vandetanib inhibits VEGFR-dependent tumor...
| Keywords: | ZD6474 |
| Application: | VEGFR / EGFR Kinase inhibitor |
| CAS | 443913-73-3 |
| MW: | 475,35 D |
From 82.00€ *
Alectinib, Free Base Item number: LC-A-2300_100mg
Soluble in DMSO.. Alectinib, also known as CH 5424802, is a potent, selective, and orally available ALK inhibitor (IC50 = 1.9 nM) and has weak or no inhibition against 24 other tested protein kinases. It has selective antitumor activity against cancers with ALK gene alterations, including non-small cell lung cancer...
| Keywords: | CH 5424802 |
| Application: | Antineoplastic, Anaplastic lymphoma kinase (ALK) inhibitor |
| CAS | 1256580-46-7 |
| MW: | 482.62 D |
From 83.00€ *
Acalabrutinib, Free Base Item number: LC-A-7337_100mg
Soluble in DMSO. Acalabrutinib, also known as ACP-196, is an irreversible Bruton tyrosine kinase (BTK) inhibitor. It binds covalently to Cys481 with improved selectivity and in vivo target coverage. Acalabrutinib inhibited BTK with an IC50 of 3 nM and had improved target specificity over ibrutinib with 323-, 94-,...
| Keywords: | ACP196, ACP-196 |
| Application: | Antineoplastic, Bruton's tyrosine kinase (BTK) inhibitor |
| CAS | 1420477-60-6 |
| MW: | 465.51 D |
From 72.00€ *
Baricitinib, Free Base Item number: LC-B-1600_100mg
Soluble in DMSO. Baricitinib, also known as INCB028050, is a janus kinase (JAK) inhibitor. It potently and selectively inhibited JAK1 and JAK2 kinases with IC50 values of 5.9 nM and 5.7 nM, respectively. It inhibited intracellular signaling of multiple proinflammatory cytokines including IL-6 and IL-23, with IC50...
| Keywords: | NCB028050, LY3009104 |
| Application: | Antiinflammatory, Antirheumatic, Immunosuppressant, Janus kinase (JAK) inhibitor |
| CAS | 1187594-09-7 |
| MW: | 371.42 D |
From 71.00€ *