• Please note that we do not deliver goods between 19.12.2019 and 03.01.2020 due to public holidays. However, we are happy to accept orders for deliveries in 2020 during this period.

Products from SYNkinase

SYNkinase

SYNkinase, headquartered in Australia, is a primary producer of research-use-only biomedical reagents, which it markets to life-science and drug-discovery researchers affiliated with Universities, Research Institutes and Industry. SYNkinase was established in 2008 by Professor Andrew Wilks and Dr Xian Bu. The founders of the company have been involved in pharmaceutical drug discovery for three decades and have extensive scientific, company and board experience.

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SAR-020106
SAR-020106

Item number: SYN-1189-M001

Soluble in DMSO. SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to...
Keywords: SAR020106
Application: Chk1 inhibitor
CAS 1184843-57-9
MW: 382,9 D
From 250.00€ *
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SB203580
SB203580

Item number: SYN-1074-M005

Soluble in DMSO or ethanol. SB203580 is a specific, ATP competitive, cell-permeable inhibitor of p38 MAPK with IC(50) of 0.3-0.5µM. It is 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC(50) of 3-5µM. Target: p38 , Kinase Group: CMGC , Substrate: Serine-Threonine
Keywords: RWJ 64809, PB 203580
Application: P38 inhibitor
CAS 152121-47-6
MW: 377,4 D
From 66.00€ *
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GW-806742X
GW-806742X

Item number: SYN-1215-M001

Soluble in DMSO. Potent protein kinase VEGFR2 inhibitor (2nm range). Binds to the pseudokinase domain of MLKL and blocks cell death by necroptosis, as well. With regards to its role in necroptosis, it is an ATP-mimetic that was shown to bind recombinant mouse MLKL pseudokinase domain, which showed inhibited...
Keywords: GW806742X, AC1NS7PT, AGN-PC-0LQ49Y
Application: VEGFR2 inhibitor
CAS 579515-63-2
MW: 573,6 D
From 119.00€ *
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SP2509
SP2509

Item number: SYN-1212-M001

Soluble in DMSO. LSD1 is a promising target for cancer therapy. Epigenetic control of histone methylation is frequently associated with oncogenesis and LSD1 is overexpressed in many types of cancer. siRNA knockdown of LSD1 has been shown to suppress growth of cancer cells. SP-2528 is a selective and reversible LSD1...
Keywords: SP-2509
Application: LSD1 inhibitor
CAS 1423715-09-6
MW: 437,9 D
From 158.00€ *
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Vorinostat
Vorinostat

Item number: SYN-3006-M005

Solid. Soluble in DMSO or ethanol. Almost insoluble in water. Vorinostat (SAHA, MK0683, Zolinza) inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC50< 86 nM). These enzymes catalyze the removal of acetyl groups from the lysine...
Keywords: SAHA, MK0683, Zolinza
Application: HDAC inhibitor
CAS 149647-78-9
MW: 264,3 D
From 53.00€ *
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AZD-8055
AZD-8055

Item number: SYN-1166-M100

Soluble in DMSO or ethanol. AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase activity with an IC(50) of 0.8nM. It shows excellent selectivity (~1,000-fold) against all class I phosphatidylinositol 3-kinase (PI3K) isoforms and other members of the PI3K-like kinase family. Target: mTOR , Kinase Group:...
Keywords: AZD8055, CCG168
Application: MTOR inhibitor
CAS 1009298-09-2
MW: 465,5 D
From 79.00€ *
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KU-55933
KU-55933

Item number: SYN-1051-M005

Soluble in DMSO or ethanol. KU55933 is a potent and selective ATP-competitive inhibitor of ATM, with an IC(50) of 13nM and a Ki of 2.2nM. KU55933 has potential for use as a new radio- and chemo-sensitizing agent for the treatment of cancer. Target: ATM , Kinase Group: Atypical (PIKK) , Substrate: Serine-Threonine
Keywords: KU55933
Application: ATM inhibitor
CAS 587871-26-9
MW: 395,5 D
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SB202190
SB202190

Item number: SYN-1073-M005

Soluble in DMSO or ethanol. SB202190 is potent and selective inhibitor of the p38alpha and beta, with IC(50) values of 50 and 100nM respectively. It is a powerful regulator of LPS-induced mRNAs in monocytes. Target: p38 , Kinase Group: CMGC , Substrate: Serine-Threonine
Keywords: SB-202190
Application: P38 alpha / beta inhibitor
CAS 152121-30-7
MW: 331,4 D
From 66.00€ *
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GSK-1120212
GSK-1120212

Item number: SYN-1170-M010

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC(50) values of 0.92nM and 1.8nM respectively. Target: MEK1 - MEK2 , Kinase Group: STE , Substrate: Serine-Threonine
Keywords: JTP-74057, GSK212, Trametinib
Application: MEK1 / MEK2 inhibitor
CAS 871700-17-3
MW: 615,4 D
From 106.00€ *
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ABT-737
ABT-737

Item number: SYN-1001-M001

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate...
Keywords: ABT737
Application: Bcl-2 / Bcl-X(L) / Bcl-w inhibitor
CAS 852808-04-9
MW: 813,4 D
From 79.00€ *
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H1152
H1152

Item number: SYN-1221-M001

Solid. Soluble in DMSO. H-1152 is a potent, specific, ATP-competitive and cell permeable ROCK inhibitor, with an IC50 of 12nM for ROCKII. H-1152 poorly inhibits PKA, PKC and myosin light chain kinase. Rho kinase (ROCK) activated by GTP-linked Rho phosphorylates targets that are involved in cytoskeletal remodelling,...
Keywords: (S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride, H1152
Application: Cell-permeable ROCK inhibitor
CAS 871543-07-6
MW: 392,3 D
From 106.00€ *
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LY-294002
LY-294002

Item number: SYN-1108-M005

Soluble in DMSO or ethanol. LY294002 is a selective and reversible PI3K inhibitor with an IC(50) range of 0.5 - 1µM. Target: PI3K , Kinase Group: Lipid Kinase , Substrate: Lipid
Keywords: LY-294002
Application: PI3K inhibitor
CAS 154447-36-6
MW: 307,3 D
From 66.00€ *
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