Products from SYNkinase
SYNkinase, headquartered in Australia, is a primary producer of research-use-only biomedical reagents, which it markets to life-science and drug-discovery researchers affiliated with Universities, Research Institutes and Industry. SYNkinase was established in 2008 by Professor Andrew Wilks and Dr Xian Bu. The founders of the company have been involved in pharmaceutical drug discovery for three decades and have extensive scientific, company and board experience.
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SB203580
Item number: SYN-1074-M010
Soluble in DMSO or ethanol. SB203580 is a specific, ATP competitive, cell-permeable inhibitor of p38 MAPK with IC(50) of 0.3-0.5µM. It is 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC(50) of 3-5µM. Target: p38 | Kinase Group: CMGC | Substrate: Serine-Threonine
| Application: | P38 inhibitor |
| CAS | 152121-47-6 |
| MW: | 377,4 D |
| Purity: | >95% |
| Format: | Solid |
From 66.00€
BX-912
Item number: SYN-1027-M100
Soluble in DMSO or ethanol. BX912 is a PDK1 (3-Phosphoinositide-dependent Kinase-1) inhibitor, with an IC(50) of 26nM. Target: PDK1 | Kinase Group: AGC | Substrate: Serine-Threonine
| Application: | PDPK1 inhibitor |
| CAS | 702674-56-4 |
| MW: | 471,4 D |
| Purity: | >95% |
| Format: | Solid |
From 86.00€
Momelotinib
Item number: SYN-1035-M100
Soluble in DMSO. CYT387 is selective inhibitor of JAK1 and JAK2 kinases including the JAK2V617F mutant . Using ATP kinase assays IC(50) values for JAK1 (11nm), JAK2, (18nM), JAK2, JAK2V617F (23nM) JAK3 (155nM), and TYK2 (17nM). In testing kinase arrays, CYT387 also had activity (defined as an IC(50) < 100nM) detected against CDK2/cyclin A, MAPK8 (JNK1), PRKCN (PKD3), PRKD1...
| Application: | JAK1 / JAK2 inhibitor |
| CAS | 1056634-68-4 |
| MW: | 414,5 D |
| Purity: | >95% |
| Format: | Solid |
From 106.00€
IC87114
Item number: SYN-1045-M100
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. IC87114 is a potent, ATP-competitive, and selective inhibitor of PI3Kdelta. IC(50) values (130-500nM) for IC87114 are sub-micromolar over a wide range of ATP concentrations from 10µM to 200µM. IC87114 can selectively inhibit cellular migration but not adhesion as well as cellular polarization. More recent work has shown...
| Application: | PI3K delta inhibitor |
| CAS | 371242-69-2 |
| MW: | 397,4 D |
| Purity: | >95% |
| Format: | Solid |
From 79.00€
Motesanib
Item number: SYN-1055-M100
Soluble in DMSO or ethanol. Motesanib (AMG 706) is a multi-targeted anti-cancer agent with an inhibitory action on human vascular endothelial growth factor receptors 1, 2 and 3 (VEGFR1-3) with IC(50) values of 2nM, 3nM and 6nM. It also inhibits platelet-derived growth factor receptor (PDGFR) and cellular stem-cell factor receptor (c-KIT). Target: PDGFR | Kinase Group: RTK |...
| Application: | VEGFR / PDGFR inhibitor |
| CAS | 453562-69-1 |
| MW: | 373,5 D |
| Purity: | >95% |
| Format: | Solid |
From 86.00€
Lapatinib
Item number: SYN-1052-M100
Soluble in DMSO or ethanol. Lapatinib is an ATP-competitive epidermal growth factor receptor (EGFR) and HER2/neu (ErbB-2) dual tyrosine kinase inhibitor, with IC(50) values of 10.8 and 9.2nM respectively. It is an orally active drug for treatment of breast cancer and other solid tumors. Target: EGFR | Kinase Group: RTK | Substrate: Tyrosine
| Application: | EGFR / ErbB2 inhibitor |
| CAS | 231277-92-2 |
| MW: | 581,1 D |
| Purity: | >95% |
| Format: | Solid |
From 66.00€
PD-0325901
Item number: SYN-1059-M100
Soluble in DMSO or ethanol. PD0325901 is selective and non ATP-competitive MEK inhibitor with an IC(50) of 0.33nM, roughly 500-fold more potent than CI-1040 on the phosphorylation of ERK1 and ERK2. Target: MEK | Kinase Group: STE | Substrate: Serine-Threonine
| Application: | MEK inhibitor |
| CAS | 391210-10-9 |
| MW: | 482,2 D |
| Purity: | >95% |
| Format: | Solid |
From 66.00€
Merck-5
Item number: SYN-1054-M100
Soluble in DMSO. Merck 5, also known as Pyridone 6, is a potent and reversible ATP-competitive inhibitor of the JAK kinases (JAK1, JAK2, JAK3, and Tyk2) with IC(50) values in the low anomolar range. At higher values (IC(50) >100nM) Merck 5 also can inhibit ERK kinase family and appear to block IL-2 and IL-4 dependent proliferation of CTLL cells and inhibits the...
| Application: | JAK / Tyk2 inhibitor |
| CAS | 457081-03-7 |
| MW: | 309,3 D |
| Purity: | >95% |
| Format: | Solid |
From 256.00€
SB-590885
Item number: SYN-1077-M100
Soluble in DMSO or ethanol. SB-590885 is a novel, potent and selective small molecule inhibitor of B-Raf kinase, with a Ki of 0.16nM. It shows an 11-fold greater selectivity for B-Raf over c-Raf. It was used to address the dependence of MAPK signalling and tumor cell growth on B-Raf kinase activity. Target: ARaf - Raf - CRaf - BRaf | Kinase Group: TKL | Substrate:...
| Application: | BRAF inhibitor |
| CAS | 405554-55-4 |
| MW: | 453,5 D |
| Purity: | >95% |
| Format: | Solid |
From 106.00€
SU-6668
Item number: SYN-1085-M100
Soluble in DMSO or ethanol. SU-6668 is a potent ATP-competitive PDGFR, VEGF and FGFR inhibitor. It has a Ki of 8nM against PDGFR. It is an anti-angiogenic and anti-tumor agent that induces regression of established tumors. Target: FGFR - PDGFR | Kinase Group: RTK | Substrate: Tyrosine
| Application: | PDGFR / FGFR1 / VEGFR2 inhibitor |
| CAS | 252916-29-3 |
| MW: | 310,4 D |
| Purity: | >95% |
| Format: | Solid |
From 66.00€
Pazopanib hydrochloride
Item number: SYN-1058A-M100
Soluble in DMSO or ethanol. Pazopanib hydrochloride (GW786034, Votrient, Armala) is a novel, multitargeted inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, FGFR, c-Kit and c-fms with IC(50) values of 10nM, 30nM, 47nM, 84nM, 74nM, 140nM and 146nM, respectively. Target: VEGFR - PDGFR | Kinase Group: RTK | Substrate: Tyrosine
| Application: | VEGFR / PDGFR / c-KIT inhibitor |
| CAS | 635702-64-6 |
| MW: | 474,0 D |
| Purity: | >95% |
| Format: | Solid |
From 66.00€
Intedanib
Item number: SYN-1091-M100
Soluble in DMSO. Intedanib is an indolinone derivative that potently inhibits VEGFR1/2/3, FGFR1/2/3 and PDGFRalpha/beta with IC(50) values of 34, 13, 13, 69, 37, 108, 59 and 65nM. Target: FGFR - PDGFR | Kinase Group: RTK | Substrate: Tyrosine
| Application: | FGFR / PDGFR / VEGFR inhibitor |
| CAS | 656247-17-5 |
| MW: | 539,6 D |
| Purity: | >95% |
| Format: | Solid |
From 106.00€
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