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Item number: A810-003
A700-016 Rabbit anti-CD3E Recombinant Monoclonal Antibody [BL-298-5D12], A500-018A Mouse anti-CD68 Recombinant Monoclonal Antibody, Purified [KP-1], A500-017A Mouse anti-CD20 Monoclonal Antibody, Purified [L26]
|Keywords:||Anti-T3E, Anti-CD3e, Anti-CD3E, Anti-T-cell surface glycoprotein CD3 epsilon chain, Anti-T-cell surface antigen T3/Leu-4...|
Item number: A810-005
PathPlex Panel 5 identifies total T-cells (CD3), cytotoxic T-cells (CD8) and cells expressing the immune checkpoint ligand PD-L1 within the context of the tumor microenvironment. PD-L1 can be expressed on antigen presenting cells such as macrophages (CD68) or tumor cells (cytokeratin). Ki-67 is a proliferation...
|Keywords:||GeneID 916, 925, 968, 4288, 29126, 3858, 3861, 3866, 3868, 3880|
Item number: A810-007
PathPlex Panel 7 identifies total cytotoxic T-cells (CD8), T-helper cells (CD4), memory T-cells (CD45RO) and regulatory T-cells (FoxP3) within the context of the tumor microenvironment. Tumor cells are identified by cytokeratin.
|Keywords:||GeneID 925, 3858, 3861, 3866, 3868, 3880, 5788, 920, 50943|
Item number: A810-008
PathPlex Panel 8 identifies total T-cells (CD3), T-helper cells (CD4), cytotoxic T-cells (CD8) and regulatory T-cells (FoxP3) within the tumor microenvironment. Lag3 is a checkpoint inhibitor which identifies exhausted T-cells. Tumor cells are identified by cytokeratin.
|Keywords:||GeneID 916, 3858, 3861, 3866, 3868, 3880, 925, 920, 3902, 50943|
Item number: A810-004
PathPlex Panel 4 identifies total T-cells (CD3), cytotoxic T-cells (CD8) and regulatory T-cells (FoxP3) within the context of the tumor microenvironment. Antigen presenting cells such as macrophages (CD68) or tumor cells (cytokeratin) express immune checkpoint ligands such as PD-L1 which inhibits the ability of...
|Keywords:||GeneID 916, 925, 968, 29126, 50943, 3858, 3861, 3866, 3868, 3880|
Item number: A810-006
PathPlex Panel 6 identifies total T-cells (CD3) and cytotoxic T-cells (CD8) and activated cytotoxic T-cells (Granzyme B) within the tumor microenvironment. The inclusion of multiple tumor cell makers (cytokeratin, Sox10 and Ki-67) provides flexibility across multiple tumor types.
|Keywords:||GeneID 3880, 3868, 3866, 3861, 3858, 916, 3002, 925, 4288, 6663|
Item number: ARG30155.1
Smad transcription factors convey downstream messages from the most versatile cytokine signaling pathways in the multicellular life forms, the transforming growth factor-beta (TGFbeta) pathway. Recent works has shed light into the processes and functions of SMAD activation and deactivation, nucleocytoplasmic...
|Keywords:||Anti-phospho-BSP1, Anti-phospho-Smad1, Anti-phospho-JV4-1, Anti-phospho-SMAD1, Anti-phospho-BSP-1, Anti-phospho-hSMAD1,...|
|Reactivity:||Human, Mouse, Rat|
Item number: ARG30162.1
A cytotoxic T cell is a T lymphocyte that kills cancer cells, virally infected cells and cells that are under damage. Most T lymphocytes express a subset of surface markers such as CD8, CD45 and CD54. CD28 expresses on the surface of T cells and provide co-stimulatory signals required for T cell activation.
|Keywords:||Anti-CD28, Anti-TP44, Anti-T-cell-specific surface glycoprotein CD28|
Item number: ARG30169.1
The Src family of protein tyrosine kinases, which includes Src, Lyn, Fyn, Yes, Lck, Blk, and Hck, are important in the regulation of growth and differentiation of eukaryotic cells. Src activity is regulated by tyrosine phosphorylation at two sites, but with opposing effects. While phosphorylation at Tyr416 in the...
|Keywords:||Anti-SRC, Anti-SRC1, Anti-p60-Src, Anti-pp60c-src, EC=220.127.116.11, Anti-Proto-oncogene c-Src, Anti-Proto-oncogene...|
|Application:||WB, ICC, IF|
Item number: ARG30170.1
Src and Src-family protein-tyrosine kinases are regulatory proteins that play key roles in cell differentiation, motility, proliferation, and survival. The initially described phosphorylation sites of Src include an activating phosphotyrosine 418 that results from autophosphorylation, and an inhibiting...
|Keywords:||Anti-phospho-SRC, Anti-phospho-SRC1, Anti-phospho-p60-Src, Anti-phospho-pp60c-src, EC=18.104.22.168,...|
Item number: ARG30182.1
AMP-activated protein kinase (AMPK) responds to hormonal and nutrient signals in the central nervous system and peripheral tissues, modulating food intake and whole-body energy homeostasis. The kinase is activated by an elevated AMP/ATP ratio due to cellular and environmental stress, such as heat shock, hypoxia and...
|Keywords:||Anti-AMPK, Anti-PRKAA2, EC=22.214.171.124, Anti-HMGCR kinase, EC=126.96.36.199, EC=188.8.131.52, Anti-ACACA kinase, Anti-AMPK subunit...|