Products from Cayman Chemical

Cayman

Cayman Chemical Company, headquartered in Ann Arbor, Michigan, is helping make research possible by supplying scientists with biochemical tools in research disciplines such as cancer, nitric oxide, neuroscience, apoptosis, oxidative injury, endocrinology, and much more. Cayman Chemical specializes in assay kits for the measurement of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones, and nitric oxide. In addition, Cayman Chemical offers a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.

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GSK4027
GSK4027

Item number: Cay23421-10

GSK4027 is a p300/CBP-associated factor (PCAF)/general control nonderepressible 5 (GCN5) bromodomain inhibitor (Ki = 1.4 nM, IC50 = 60 nM in a chromatin engagement assay). It is greater than 18,000-fold selective for PCAF and GCN5 over BET family bromodomains and greater than 70-fold selective over other bromodomain...
Keywords: 4-bromo-2-methyl-5-[[(3R,5R)-1-methyl-5-phenyl-3-piperidinyl]amino]-3(2H)-pyridazinone
Application: PCAF / GCN5 bromodomain inhibitor
CAS 2079896-25-4
MW: 377.3 D
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5-Hydroxymethylfurfural
5-Hydroxymethylfurfural

Item number: Cay27835-5

5-Hydroxymethylfurfural is a furanic compound derived from the degradation of sugars. It can be derived from reducing sugars via acid-catalyzed degradation or the Maillard reaction during the heating and storage of foods. 5-Hydroxymethylfurfural is an intermediate in the synthesis of a variety of compounds including...
Keywords: HMF, NSC 40738, 5-(hydroxymethyl)-2-furancarboxaldehyde
Application: Radical scavenger
CAS 67-47-0
MW: 126.1 D
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Arachidic Acid-d2
Arachidic Acid-d2

Item number: Cay28083-5

Arachidic acid-d2 is intended for use as an internal standard for the quantification of arachidic acid (Cay-9000339, Cay-21906) by GC- or LC-MS. Arachidic acid is a long-chain saturated fatty acid that has been found in peanut butter and anaerobic fungi. It inhibits rabbit neutrophil aggregation induced by...
Keywords: Arachic Acid-d2, Eicosanoate-d2, Icosanoic Acid-d2, eicosanoic-2,2-d2 acid
Application: GC-MS, LC-MS, Internal standard, Quantification, Saturated long-chain fatty acid
CAS 232600-70-3
MW: 314.5 D
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Ferrostatin-1
Ferrostatin-1

Item number: Cay17729-5

Ferrostatin-1 is a ferroptosis inhibitor. It inhibits cell death induced by the ferroptosis inducers erastin (Cay-17754, EC50 = 60 nM) and RSL3, but not by hydrogen peroxide, rotenone, or staurosporine, in HT-1080 cells when used at a concentration of 0.5 µM. Ferrostatin-1 (0.5 µM) inhibits erastin-induced...
Keywords: Fer-1, 3-amino-4-(cyclohexylamino)-benzoic acid, ethyl ester
Application: Ferroptosis inhibitor
CAS 347174-05-4
MW: 262.4 D
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Stearidonic Acid ethyl ester
Stearidonic Acid ethyl ester

Item number: Cay10006856-1

Stearidonic acid (18:4omega-3) is a rare polyunsaturated fatty acid of the omega-3 series. In normal humans, it represents less than 0.25% of serum phospholipid fatty acids. It is present in certain natural oils such as echium and black currant seed, and to the extent that these oils are incorporated into...
Keywords: Ethyl Stearidonate, Moroctic Acid ethyl ester, 6Z,9Z,12Z,15Z-octadecatetraenoic acid, ethyl ester
Application: Bioactive lipid assays
CAS 119798-44-6
MW: 304.5 D
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Prostaglandin E2-d9
Prostaglandin E2-d9

Item number: Cay10581-250

PGE2-d9 contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20' positions. It is intended for use as an internal standard for the quantification of PGE2 by GC- or LC-mass spectrometry (MS). PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely...
Keywords: Dinoprostone-d9, PGE2-d9, 9-oxo-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic-17,17,18,18,19,19,20,20,20-d9 acid
Application: Standard
CAS 1356347-42-6
MW: 361.5 D
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BAPTA
BAPTA

Item number: Cay11706-100

BAPTA is a membrane-impermeable calcium chelator that binds extracellular calcium ions. The presence of four carboxylic acid functional groups allows for the binding of two calcium ions. BAPTA and its derivatives are widely used for the measurement and manipulation of intracellular free calcium concentration.
Keywords: N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)-glycine
Application: Calcium chelator
CAS 85233-19-8
MW: 476.4 D
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Streptozotocin
Streptozotocin

Item number: Cay13104-100

Streptozotocin (STZ) is a glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals. It specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. DNA damage induces activation of poly ADP-ribosylation, depletion of cellular NAD+ and...
Keywords: Estreptozocin, NSC 37917, NSC 85998, STZ, U 9889, Zanosar, 2-deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose
Application: Diabetes inducer, NO donor
CAS 18883-66-4
MW: 265.2 D
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Oleoyl Serinol
Oleoyl Serinol

Item number: Cay13637-100

Oleoyl serinol is an analog of ceramide and an agonist of the cannabinoid receptor GPR119 that has an EC50 value of 12 µM for stimulating secretion of GLP-1 in mouse endocrine GLUTag cells. It has been found in E. coli that express human microbiota N-acyl synthase (hmNAS) genes. It induces cell death of F-11 murine...
Keywords: N-Oleoyl Serinol, S-18, N-[2-hydroxy-1-(hydroxymethyl)ethyl]-9Z-octadecenamide
Application: GPR119 agonist
CAS 72809-08-6
MW: 355.6 D
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D-(-)-3-Phosphoglyceric Acid (sodium salt)
D-(-)-3-Phosphoglyceric Acid (sodium salt)

Item number: Cay20123-10

D-(-)-3-Phosphoglyceric acid is an intermediate in several biological pathways, most notably glycolysis/gluconeogenesis and the biosynthesis of serine, glycine, and threonine. It also has numerous roles as an intermediate in biosynthetic pathways in plants, eukaryotes, and prokaryotes.
Keywords: 2R-hydroxy-3-(phosphonooxy)-propanoic acid, disodium salt
Application: Glycolysis intermediate, Serine precursor
CAS 80731-10-8
MW: 230 D
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N6-Benzyladenine
N6-Benzyladenine

Item number: Cay21711-25

N6-Benzyladenine (6-BAP) is a synthetic cytokinin that stimulates plant growth and regulates de novo bud development, leaf expansion, delay of senescence, and chloroplast formation in plants. 6-BAP inhibits respiratory kinase in plants and increases post-harvest life of green vegetables. 6-BAP also increases lipid...
Keywords: 6-BAP, N6-Benzylaminopurine, NSC 40818, SQ 4,609, N-(phenylmethyl)-9H-purin-6-amine
Application: Synthetic cytokinin, Plant growth stimulator, Respiratory kinase inhibitor
CAS 1214-39-7
MW: 225.3 D
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Yoda1
Yoda1

Item number: Cay21904-1

Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 µM for murine and human Piezo1-transfected HEK293T cells, respectively). It is selective for Piezo1 as it elicits Ca2+ flux in Piezo1- but not Piezo2-transfected HEK293T cells. Yoda1 slows the inactivation phase of murine Piezo1 transient currents and...
Keywords: 2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-pyrazine
Application: Piezo1 agonist
CAS 448947-81-7
MW: 355.3 D
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