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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-RQ4791 | 100 µl | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. Protein inhibitor of... more
Product information "Anti-PIAS1/2/3, clone ABFA-16"
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. Protein inhibitor of activated STAT (PIAS), also known as E3 SUMO-protein ligase PIAS, is a protein that regulates transcription in mammals. PIAS proteins act as transcriptional co-regulators with at least 60 different proteins in order to either activate or repress transcription. The transcription factors STAT, NF-kappaB, p73, and p53 are among the many proteins that PIAS interacts with. PIAS proteins have potential applications in cancer treatment and prevention. They may also play an important role in regulating immune system responses. [Wiki] Protein function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB. Mediates the nuclear mobility and localization of MSX1 to the nuclear periphery, whereby MSX1 is brought into the proximity of target myoblast differentiation factor genes. Also required for the binding of MSX1 to the core enhancer region in target gene promoter regions, independent of its sumolyation activity. Capable of binding to the core enhancer region TAAT box in the MYOD1 gene promoter. [The UniProt Consortium]
Keywords: | Anti-GBP, Anti-PIAS1, Anti-DDXBP1, EC=2.3.2.-, Anti-Gu-binding protein, Anti-DEAD/H box-binding protein 1, Anti-E3 SUMO-protein ligase PIAS1, Anti-RNA helicase II-binding protein, Anti-E3 SUMO-protein transferase PIAS1, PIAS1/2/3 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | RQ4791 |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | ABFA-16 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A synthetic peptide specific to human PIAS 1 & 2 & 3 |
Format: | Purified |
Database Information
KEGG ID : | K04706 | Matching products |
UniProt ID : | O75925 | Matching products |
Gene ID | GeneID 8554 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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