Products from Chimerigen

Chimerigen

Chimerigen manufactures unique immunoglobulin based chimeric fusion proteins and their related research products using advanced cellular and molecular biological techniques. These reagents are used successfully in basic and applied research.

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IL-2 (human) Superkine (Fc) MultiPack
IL-2 (human) Superkine (Fc) MultiPack

Item number: CHI-ZHF-21002S-C010

3 x 10 µg. Triggers far greater antitumor responses than native IL-2 in vivo but with lower toxicity. The extracellular domain of human IL-2 (aa 21-153) (mutant H9 containing the mutations L80F / R81D / L85V / I 86V / I92F) is fused at the C-terminus to the Fc portion of human IgG2. Binds to human and mouse IL-2R. IL-2 Protein function: Produced by T-cells in response to...
Application: Bioassays
Host: Human cells
Reactivity: Human
Purity: >95%
Format: Lyophilized
From 330.00€
Review
CX3CL1, Soluble (human) (rec.)
CX3CL1, Soluble (human) (rec.)

Item number: CHI-AG-40A-0079-C050

CX3CL1 [Fractalkine] is expressed on TNF-alpha and IL-1 activated endothelial cells (ECs) and binds to CX3CR1. CX3CL1 can exist in 2 forms, as membrane-anchored or as a shed 95-kDa glycoprotein. The soluble CX3CL1 has potent chemoattractant activity for T cells and monocytes, and the cell surface bound protein, which is induced on activated primary endothelial cells,...
Application: Bioassays
Host: Human cells
Reactivity: Human
MW: ~50 kD
Purity: >90%
Format: Lyophilized
From 187.00€
Review
IL-2 (human) (rec.) (His)
IL-2 (human) (rec.) (His)

Item number: CHI-HF-20102-C050

Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and...
Application: Bioassays
Host: Human cells
Reactivity: Human
MW: ~19 kD
Purity: >95%
Format: Lyophilized
From 182.00€
Review
EGF (human) (rec.) (His)
EGF (human) (rec.) (His)

Item number: CHI-HF-201EGF-C050

Epidermal growth factor (EGF) is a growth factor and the founding member of the EGF family. All EGF family members are synthesized as type I transmembrane precursor proteins that may contain several EGF domains in the extracellular region. The mature proteins are released from the cell surface by regulated proteolysis. EGF is present in various body fluids, including blood,...
Application: Bioassays
Host: Human cells
Reactivity: Human
MW: ~10 kD
Purity: >95%
Format: Lyophilized
From 182.00€
Review
CCL24 (human):Fc (human) (rec.)
CCL24 (human):Fc (human) (rec.)

Item number: CHI-HF-210CCL24-C050

CCL24 (eotaxin-2) has been shown to induce chemotaxis of eosinophils, basophils and resting T lymphocytes but not monocytes and activated T lymphocytes. CCL24 is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils. Elevated levels of CCL24 has been...
Application: Bioassays
Host: Hamster cells
Reactivity: Human
Purity: >98%
Format: Lyophilized
From 160.00€
Review
IL-22 (human):Fc (human) (rec.)
IL-22 (human):Fc (human) (rec.)

Item number: CHI-HF-21022-C050

The extracellular domain of human IL-22 (aa 34-179) is fused at the C-terminus to the Fc portion of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1...
Application: Bioassays
Host: Hamster cells
Reactivity: Human
Purity: >98%
Format: Lyophilized
From 264.00€
Review
IL-4 (human):Fc (human) (rec.) (non-lytic)
IL-4 (human):Fc (human) (rec.) (non-lytic)

Item number: CHI-HF-22004-C050

The extracellular domain of human IL-4 (aa 25-153) is fused at the C-terminus to the Fc portion of a mutant human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Shows the biological function of the IL-4 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2...
Application: Bioassays
Host: Mouse cells
Reactivity: Human
Purity: >98%
Format: Lyophilized
From 215.00€
Review
IL-22 (human):Fc (human) (rec.) (non-lytic)
IL-22 (human):Fc (human) (rec.) (non-lytic)

Item number: CHI-HF-22022-C050

The extracellular domain of human IL-22 (aa 34-179) is fused at the C-terminus to the Fc portion of a mutant human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Shows the biological function of the IL-22 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible...
Application: Bioassays
Host: Hamster cells
Reactivity: Human
Purity: >98%
Format: Lyophilized
From 281.00€
Review
CSF3 (mouse):Fc (mouse) (rec.)
CSF3 (mouse):Fc (mouse) (rec.)

Item number: CHI-MF-110CSF3-C050

G-CSF is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation and activation of hematopoietic cells of the neutrophilic granulocyte lineage. It is produced mainly by monocytes and macrophages upon activation by endotoxin, TNF-alpha and IFN-gamma. Other cell types including fibroblasts, endothelial cells, astrocytes and bone marrow...
Application: Bioassays
Host: Hamster cells
Reactivity: Mouse
Purity: >98%
Format: Lyophilized
From 182.00€
Review
IL-10 (human) (rec.) (His)
IL-10 (human) (rec.) (His)

Item number: CHI-HF-20110-C050

Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as...
Application: Bioassays
Host: Human cells
Reactivity: Human
MW: ~18 kD
Purity: >95%
Format: Lyophilized
From 220.00€
Review
IL-4 (mouse):Fc (mouse) (rec.) (non-lytic)
IL-4 (mouse):Fc (mouse) (rec.) (non-lytic)

Item number: CHI-MF-12004-C050

The extracellular domain of mouse IL-4 (aa 21-140) is fused at the C-terminus to the Fc portion of a mutant mouse IgG2a. Lyophilized from 0.2µm-filtered solution in PBS. Shows the biological function of the IL-4 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2...
Application: Bioassays
Host: Mouse cells
Reactivity: Mouse
Purity: >98%
Format: Lyophilized
From 215.00€
Review
FGF-19 (human) (rec.) (His)
FGF-19 (human) (rec.) (His)

Item number: CHI-AG-40A-0111-C050

FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity...
Application: Bioassays
Host: Human cells
Reactivity: Human
MW: ~22 kD
Purity: >90%
Format: Lyophilized
From 198.00€
Review
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