Products from Innaxon

Innaxon

Innaxon is a company based at in Tewkesbury, United Kingdom focussing on innate immunity, TLR agonists and small molecule inhibitors for research on innate immunity.

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Monophosphoryl Lipid A [MPLA] from E. coli R515 (Re) TLRpure Sterile Solution
Monophosphoryl Lipid A [MPLA] from E. coli R515 (Re)...

Item number: IAX-100-003-M001

Optimal concentration is dependent upon cell type, species, desired activation and analysis: 0.1-1.0 µg/ml. Does not activate any TLR other than TLR4 as tested up to 50 µg/ml in relevant cellular systems (macrophages). Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4), a member of the highly...
Keywords: Monophosphoryl Lipid A [MPLA] derived from E. coli R515 (Re) LPS (biosynthetic)
Application: TLR4 activator
From 125.00€ *
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G-type iODN (inhibitory ODN) Endotoxin-free (sterile)
G-type iODN (inhibitory ODN) Endotoxin-free (sterile)

Item number: IAX-200-052-M001

Potent sequence of an inhibitory ODN of the poly-G class I targeting TLR9, but without effect on TLR7 and TLR8 signaling, for in vivo use in rodents (50-150 µg per injection). Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
Keywords: Inhibitory ODN (iODN): Class I
Application: TLR9 competitor
MW: 6735 D
From 98.00€ *
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ODN 2138 (Control for ODN 1826) Endotoxin-free (sterile)
ODN 2138 (Control for ODN 1826) Endotoxin-free (sterile)

Item number: IAX-200-201-C100

Negative control GpC ODN for in vivo use in rodents (50-150 µg per injection). As active compound use CpG ODN 1826 (Cat. No.: IAX-200-002). For negative control without agonistic nor antagonistic activity: Neutral-ODN (Cat. No.: IAX-200-202).
Application: Negative Control for ODN 1826 (IAX-200-002)
MW: 6383 D
98.00€ *
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Polyinosinic-polycytidylic acid [Poly(I:C)] Endotoxin-free (sterile)
Polyinosinic-polycytidylic acid [Poly(I:C)]...

Item number: IAX-200-021-M005

Activates TLR3, MDA5/Helicard and RIG-I. Optimal working concentration depends upon target receptor accessibility, number, density, as well as cell type, and therefore needs to be determined for each application. Recommended concentration range: in vitro: 0.5-10 µg/ml, in vivo: 5mg/kg.
Keywords: Polyinosinic-polycytidylic acid, potassium salt (poly (I:C))
Application: TLR3, MDA5/Helicard, RIG-I activator
From 112.00€ *
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ODN 1668 (Type B) Endotoxin-free (sterile)
ODN 1668 (Type B) Endotoxin-free (sterile)

Item number: IAX-200-001-M001

3 x 1 mg. Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 1720 (Cat. No.: IAX-200-200).
Keywords: CpG ODN TLR9 Agonist: B Type (species: rodent)
Application: TLR9 activator
MW: 6383 D
From 125.00€ *
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ODN M362 (Type C) Endotoxin-free (sterile)
ODN M362 (Type C) Endotoxin-free (sterile)

Item number: IAX-200-004-M001

Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 2243 (Cat. No.: IAX-200-205).
Keywords: CpG ODN TLR9 Agonist: A Type (species: human and rodent)
Application: TLR9 activator
MW: 6644 D
From 125.00€ *
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Physiological Saline [Sodium Chloride 0.9%] Endotoxin-free (sterile)
Physiological Saline [Sodium Chloride 0.9%]...

Item number: IAX-900-003-3010

Chemical. Use for the dilution of TLRpureTM LPS and solubilisation of endotoxin-free reagents (e.g. ODNs).
Keywords: Sodium Chloride 0.9%
CAS 7647-14-5
From 25.00€ *
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IAXO-101 (CD14/TLR4 Antagonist) (synthetic)
IAXO-101 (CD14/TLR4 Antagonist) (synthetic)

Item number: IAX-600-001-M001

Described to interfere with human, rat and mouse TLR4/CD14 signaling, other species not tested. Optimal working concentration depends upon the type, purity and concentration and of TLR4 ligand, carrier protein such as LPS-binding protein (LBP), soluble and membrane-bound CD14, the presence of TLR4 co-receptors (e.g....
Keywords: Methyl 6-deoxy-6-N-dimethyl-N-cyclopentylammonium-2,3-di-O-tetradecyl-?-D-glucopyranoside iodide
Application: CD14/TLR4 Antagonist
CAS 1202388-64-4
MW: 810.02 D
From 237.00€ *
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LPS (Universal) from S. abortus equi (S-form) TLRpure Sterile Solution
LPS (Universal) from S. abortus equi (S-form) TLRpure...

Item number: IAX-100-009-M001

Optimal concentration is dependent upon cell type, species, desired activation and analysis: 0.01-1.0 µg/ml. Does not activate any TLR other than TLR4 as tested up to 50 µg/ml in relevant cellular systems (macrophages). Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4). For optimal...
Keywords: Lipopolysaccharide (LPS) from Salmonella abortus equi, S-type (smooth/wild-type) LPS
Application: TLR4 activator
From 95.00€ *
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ODN 1826 (Type B) Endotoxin-free (sterile)
ODN 1826 (Type B) Endotoxin-free (sterile)

Item number: IAX-200-002-M001

Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 1982 (Cat. No.: IAX-200-201).
Keywords: CpG ODN TLR9 Agonist: B Type (species: rodent)
Application: TLR9 activator
Reactivity: Mouse, Rat
MW: 6383 D
From 125.00€ *
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ODN 2006 (Type B) Endotoxin-free (sterile)
ODN 2006 (Type B) Endotoxin-free (sterile)

Item number: IAX-200-006-M001

3 x 1 mg. Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.7-7.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 2137 (Cat. No.: IAX-200-206).
Keywords: CpG ODN TLR9 Agonist: B Type (species: human and rodent)
Application: TLR9 activator
MW: 7720 D
From 125.00€ *
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LPS from E. coli O111:B4 (S-form) TLRpure Sterile Solution
LPS from E. coli O111:B4 (S-form) TLRpure Sterile Solution

Item number: IAX-100-012-C500

Optimal concentration is dependent upon cell type, species, desired activation and analysis: 0.01-1.0 µg/ml. Does not activate any TLR other than TLR4 as tested up to 50 µg/ml in relevant cellular systems (macrophages). Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4). For optimal...
Keywords: Lipopolysaccharide (LPS) from E. coli O111:B4, S-type (smooth/wild-type) LPS
Application: TLR4 activator
From 180.00€ *
Review
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