Products from Indigo Biosciences

Indigo

Indigo Biosciences, Inc. was founded in 2005 in State College, PA by Dr. Jack Vanden Heuvel and Dr. Blake Peterson. It remains a privately held biosciences company offering products and services focused on nuclear receptors, which comprise a major class of therapeutic drug targets. The company’s two founders leveraged their collective expertise’s in nuclear receptor biology, toxicology, medicinal chemistry and molecular biology to establish the core platform technology of the company.

More information at: indigobiosciences.com

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AR (human) Reporter Assay Kit
AR (human) Reporter Assay Kit

Item number: IB-IB03001

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of full-length, unmodified human androgen receptor (NR3C4), a ligand-dependent transcription factor commonly referred to as AR. INDIGO's reporter cells include the luciferase...
Keywords: AR, DHTR, Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
Application: Functional activity screening
Reactivity: Human
From 1,121.00€ *
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RORgamma (human) Reporter Assay Kit
RORgamma (human) Reporter Assay Kit

Item number: IB-IB04001

This human RAR-related orphan receptor gamma (RORgamma) mRNA is expressed from the RORC gene in two forms via alternate usage of tissue-specific promoters. Variant 1 mRNA is expressed in numerous tissues, and encodes receptor isoform 1, referred to as RORgamma. Variant 2 mRNA comprises an alternate exon 1 that...
Keywords: RORC, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, RAR-related orphan receptor C, Retinoid-related...
Application: Functional activity screening
Reactivity: Human
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PPARalpha (human) Reporter Assay Kit
PPARalpha (human) Reporter Assay Kit

Item number: IB-IB00111

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human peroxisome proliferator-activated receptor alpha (NR1C1), a ligand-dependent transcription factor commonly referred to as PPARA or PPARalpha. INDIGO's reporter cells include...
Keywords: NR1C1, PPARA, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, Peroxisome proliferator-activated receptor alpha
Application: Functional activity screening
Reactivity: Human
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FXR (human) Reporter Assay Kit
FXR (human) Reporter Assay Kit

Item number: IB-IB00601-32

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human farnesoid X receptor (NR1H4), a ligand-dependent transcription factor commonly referred to as FXR. INDIGO's reporter cells include the luciferase reporter gene...
Keywords: BAR, NR1H4, Bile acid receptor, Farnesol receptor HRR-1, RXR-interacting protein 14, Farnesoid X-activated receptor,...
Application: Functional activity screening
Reactivity: Human
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PPARgamma (human) Reporter Assay Kit
PPARgamma (human) Reporter Assay Kit

Item number: IB-IB00101

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human peroxisome proliferator-activated receptor gamma (NR1C3), a ligand-dependent transcription factor commonly referred to as PPARG or PPARgamma. INDIGO's reporter cells include...
Keywords: NR1C3, PPARG, PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, Peroxisome proliferator-activated receptor gamma
Application: Functional activity screening
Reactivity: Human
From 1,121.00€ *
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ERalpha (human) Reporter Assay Kit
ERalpha (human) Reporter Assay Kit

Item number: IB-IB00401

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the full-length human estrogen receptor 1 (NR3A1), a ligand-dependent transcription factor commonly referred to as ERalpha. INDIGO's reporter cells include the luciferase reporter gene...
Keywords: ER, ESR, ESR1, ER-alpha, Estrogen receptor, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1
Application: Functional activity screening
Reactivity: Human
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PXR (human) Reporter Assay Kit
PXR (human) Reporter Assay Kit

Item number: IB-IB07001

Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...
Keywords: SXR, PXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic...
Application: Functional activity screening
Reactivity: Human
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RARbeta (human) Reporter Assay Kit
RARbeta (human) Reporter Assay Kit

Item number: IB-IB02101

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, beta (NR1B2), a ligand-dependent transcription factor commonly referred to as RARB or RARbeta. INDIGO's reporter cells include the luciferase reporter...
Keywords: HAP, RARB, RAR-beta, RAR-epsilon, HBV-activated protein, Retinoic acid receptor beta, Nuclear receptor subfamily 1 group B...
Application: Functional activity screening
Reactivity: Human
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RARalpha (human) Reporter Assay Kit
RARalpha (human) Reporter Assay Kit

Item number: IB-IB02201

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, alpha (NR1B1), a ligand-dependent transcription factor commonly referred to as RARA or RARalpha. INDIGO's reporter cells include the luciferase...
Keywords: RARA, NR1B1, RAR-alpha, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1
Application: Functional activity screening
Reactivity: Human
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Epidermal Growth Factor Receptor 1 (EGFR1) (Human) Reporter Assay System
Epidermal Growth Factor Receptor 1 (EGFR1) (Human)...

Item number: IB-IB13001

Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin,...
Keywords: ERBB, EGFR, EC=2.7.10.1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, Receptor tyrosine-protein kinase erbB-1
Application: Functional activity screening
Reactivity: Human
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RORa (Human) Reporter Assay System
RORa (Human) Reporter Assay System

Item number: IB-IB04011-32

Protein function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid,...
Keywords: RORA, NR1F1, Nuclear receptor ROR-alpha, Nuclear receptor RZR-alpha, RAR-related orphan receptor A, Retinoid-related...
Application: Functional activity screening
Reactivity: Human
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RARgamma (human) Reporter Assay Kit
RARgamma (human) Reporter Assay Kit

Item number: IB-IB02001

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor gamma (NR1B3), a ligand-dependent transcription factor commonly referred to as RARG or RARgamma. INDIGO's reporter cells include the luciferase...
Keywords: RARG, NR1B3, RAR-gamma, Retinoic acid receptor gamma, Nuclear receptor subfamily 1 group B member 3
Application: Functional activity screening
Reactivity: Human
From 1,121.00€ *
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