Products from LKT Laboratories
LKT Laboratories, Inc., in St. Paul, Minnesota, is a research and development company focused on the discovery of specialty chemicals for cancer chemoprevention. LKT Labs produces and markets unique chemicals and biochemicals for all types of life science research and supply raw materials for manufacturing and research.
More information at: www.lktlabs.com
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Nitisinone Item number: LKT-N3476.50
Nitisinone is a nitrobenzene inhibitor of HPPD, an enzyme involved in tyrosine degradation. Nitisinone is clinically used to slow the effects of hereditary type 1 tyrosinemia and as a potential treatment for alkaptonuria.
| Keywords: | NTBC, orfadin |
| Application: | 4-hydroxyphenylpyruvate dioxygenase inhibitor |
| CAS | 104206-65-7 |
| MW: | 329.23 D |
From 63.00€ *
Carmustine Item number: LKT-C0173.100
Carmustine is an antitumor agent.
| Keywords: | BCNU, bis-chloroethylnitrosourea |
| Application: | Anticancer agent |
| CAS | 154-93-8 |
| MW: | 214,05 D |
From 75.00€ *
Isoflurane Item number: LKT-I7258.250
Isoflurane is an anesthetic most commonly used in veterinary medicine. Isoflurane exhibits cardiomodulatory, neuromodulatory, and pro-inflammatory activities. In diabetic rats, isofluorane decreases cardiac force and intracellular Ca2+ amplitude. Isoflurane also increases IL-6 and NF-kappaB levels in glioma cells...
| Application: | Anesthetic [inhalation] |
| CAS | 26675-46-7 |
| MW: | 184.49 D |
From 58.00€ *
MG132 Item number: LKT-M2400.5
MG-132 is a proteasome inhibitor that exhibits anti-fibrotic and anti-osteoarthritic activities. In renal interstitial fibroblasts, MG-132 inhibits proliferation and induces apoptosis by activating p53, p21, caspase 3, and Bax. MG-132 also inhibits skeletal muscle atrophy in animal models of chronic obstructive...
| Keywords: | MG-132 |
| Application: | Proteasome inhibitor |
| CAS | 133407-82-6 |
| MW: | 475.62 D |
From 136.00€ *
ASTX660 Item number: LKT-A744789.1
ASTX660 is an inhibitor of apoptosis proteins found to target BIR3 domain of cIAP1/2 and XIAP through a TNFalpha dependent mechanism in melanoma, breast cancer, and lymphoma cell studies. In a breast cancer xenograft model ASTX660 inhibited tumor growth while displaying no significant adverse effects. Treatment of...
| Keywords: | ASTX660, ASTX-660, ASTX 660, Ethanone,... |
| Application: | CIAP / XIAP dual antagonist |
| CAS | 1799328-86-1 |
| MW: | 539.7 D |
From 453.00€ *
Baloxavir Item number: LKT-B011458.1
Baloxavir, and its prodrug baloxavir marboxil, is a cap-dependent endonuclease inhibitor, leading to inhibition of RNA transcription and replication. Baloxavir shows potent activity against two influenza A strains with noted synergistic effects when used in combination with oseltamivir. Baloxavir has also been...
| Keywords: | Baloxavir acid, 4G86Y4JT3F,... |
| Application: | Antiviral, Cap-dependent endonuclease inhibitor |
| CAS | 1985605-59-1 |
| MW: | 483.5 D |
From 101.00€ *
Baloxavir Marboxil Item number: LKT-B011460.100
Baloxavir, and its prodrug baloxavir marboxil, is a cap-dependent endonuclease inhibitor, leading to inhibition of RNA transcription and replication. Baloxavir shows potent activity against two influenza A strains with noted synergistic effects when used in combination with oseltamivir. Baloxavir has also been...
| Keywords: | Xofluza, S-033188,... |
| Application: | Antiviral, Cap-dependent endonuclease inhibitor, Prodrug |
| CAS | 1985606-14-1 |
| MW: | 571.6 D |
From 123.00€ *
Bedaquiline Fumarate Item number: LKT-B165121.100
Bedaquiline is a diarylquinoline found to be useful in treating multidrug-resistant tuberculosis. In mouse models of TB, bedaquiline has significantly shortened the treatment regimen. A long-acting injectable formulation has been shown to have prolonged bactericidal activity. Bedaquiline inhibits ATP-synthase, and...
| Keywords: | (1R,2S)-1-(6-Bromo-2-methoxy-3-quinolinyl)-4-(dimethylamino)-2-(1-naphthyl)-1-phenyl-2-butanol (2E)-2-butenedioate (1:1) |
| Application: | Antibacterial (tuberculostatic), ATP synthase inhibitor |
| CAS | 845533-86-0 |
| MW: | 671.59 D |
From 194.00€ *
Camalexin Item number: LKT-C016481.100
Camalexin is a phytoalexin found in various cruciferous plants after exposure to environmental stresses. Studies on acute myeloid leukemia cells show that camalexin selectively decreases cell viability. Several studies have already shown that exposure to camalexin causes cell shrinkage and phospholipid scrambling in...
| Keywords: | 3-(1,3-thiazol-2-yl)-1H-indole, 3-(thiazol-2-yl)indole, 2-(1H-indol-3-yl)-1,3-thiazole |
| Application: | Bioactive phytoalexin |
| CAS | 135531-86-1 |
| MW: | 200.26 D |
From 84.00€ *
LY-3214996 Item number: LKT-L960012.100
LY-3214996 is a selective inhibitor of ERK1/2. ERK1/2 inhibitors offer a targeted approach to cancers in which the RAS/MAPK signaling pathway is dysregulated. These compounds can be successful when Braf and MEK inhibitor efficacy is lost due to developed drug resistance. LY-3214996 has demonstrated potent antitumor...
| Keywords: | LY 3214996, LY3214996, LY-3214996 |
| Application: | Selective ERK1/2 inhibitor |
| CAS | 1951483-29-6 |
| MW: | 453.57 D |
From 136.00€ *
4-(Methylsulfinyl) butylamine Item number: LKT-M185777.10
4-(Methylsulfinyl) butylamine is the synthetic precursor of sulforaphane.
| Keywords: | Schembl371434, CTK7E8172, 4-methanesulfinylbutan-1-amine, (+/-)-1-amino-4-(methylsulfinyl)butane,... |
| Application: | Synthetic sulforaphane precursor |
| CAS | 187587-70-8 |
| MW: | 135.23 D |
From 58.00€ *
L-(-)-Norepinephrine-(+)-bitartrate Item number: LKT-N582686.1
Norepinephrine is a hormone and neurotransmitter that modulates sympathetic nervous system activity and plays a role in modulating reward, reinforcement, feeding, and other behaviors. Norepinephrine exhibits vasoconstrictive, pro-angiogenic, and thermoregulatory activities. Norepinephrine is clinically used to treat...
| Keywords: | L-(-)-Norepinephrine-(+)-bitartrate, 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol, 2,3-dihydroxybutanedioic acid,... |
| Application: | Hormone, Neurotransmitter |
| CAS | 69815-49-2 |
| MW: | 319.26 D |
From 54.00€ *