Products from LKT Laboratories

LKT

LKT Laboratories, Inc., in St. Paul, Minnesota, is a research and development company focused on the discovery of specialty chemicals for cancer chemoprevention. LKT Labs produces and markets unique chemicals and biochemicals for all types of life science research and supply raw materials for manufacturing and research.

More information at: www.lktlabs.com

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Nitisinone
Nitisinone

Item number: LKT-N3476.50

Nitisinone is a nitrobenzene inhibitor of HPPD, an enzyme involved in tyrosine degradation. Nitisinone is clinically used to slow the effects of hereditary type 1 tyrosinemia and as a potential treatment for alkaptonuria.
Keywords: NTBC, orfadin
Application: 4-hydroxyphenylpyruvate dioxygenase inhibitor
CAS 104206-65-7
MW: 329.23 D
From 63.00€ *
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Carmustine
Carmustine

Item number: LKT-C0173.100

Carmustine is an antitumor agent.
Keywords: BCNU, bis-chloroethylnitrosourea
Application: Anticancer agent
CAS 154-93-8
MW: 214,05 D
From 75.00€ *
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Isoflurane
Isoflurane

Item number: LKT-I7258.250

Isoflurane is an anesthetic most commonly used in veterinary medicine. Isoflurane exhibits cardiomodulatory, neuromodulatory, and pro-inflammatory activities. In diabetic rats, isofluorane decreases cardiac force and intracellular Ca2+ amplitude. Isoflurane also increases IL-6 and NF-kappaB levels in glioma cells...
Application: Anesthetic [inhalation]
CAS 26675-46-7
MW: 184.49 D
From 58.00€ *
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MG132
MG132

Item number: LKT-M2400.5

MG-132 is a proteasome inhibitor that exhibits anti-fibrotic and anti-osteoarthritic activities. In renal interstitial fibroblasts, MG-132 inhibits proliferation and induces apoptosis by activating p53, p21, caspase 3, and Bax. MG-132 also inhibits skeletal muscle atrophy in animal models of chronic obstructive...
Keywords: MG-132
Application: Proteasome inhibitor
CAS 133407-82-6
MW: 475.62 D
From 136.00€ *
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ASTX660
ASTX660

Item number: LKT-A744789.1

ASTX660 is an inhibitor of apoptosis proteins found to target BIR3 domain of cIAP1/2 and XIAP through a TNFalpha dependent mechanism in melanoma, breast cancer, and lymphoma cell studies. In a breast cancer xenograft model ASTX660 inhibited tumor growth while displaying no significant adverse effects. Treatment of...
Keywords: ASTX660, ASTX-660, ASTX 660, Ethanone,...
Application: CIAP / XIAP dual antagonist
CAS 1799328-86-1
MW: 539.7 D
From 453.00€ *
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Baloxavir
Baloxavir

Item number: LKT-B011458.1

Baloxavir, and its prodrug baloxavir marboxil, is a cap-dependent endonuclease inhibitor, leading to inhibition of RNA transcription and replication. Baloxavir shows potent activity against two influenza A strains with noted synergistic effects when used in combination with oseltamivir. Baloxavir has also been...
Keywords: Baloxavir acid, 4G86Y4JT3F,...
Application: Antiviral, Cap-dependent endonuclease inhibitor
CAS 1985605-59-1
MW: 483.5 D
From 101.00€ *
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Baloxavir Marboxil
Baloxavir Marboxil

Item number: LKT-B011460.100

Baloxavir, and its prodrug baloxavir marboxil, is a cap-dependent endonuclease inhibitor, leading to inhibition of RNA transcription and replication. Baloxavir shows potent activity against two influenza A strains with noted synergistic effects when used in combination with oseltamivir. Baloxavir has also been...
Keywords: Xofluza, S-033188,...
Application: Antiviral, Cap-dependent endonuclease inhibitor, Prodrug
CAS 1985606-14-1
MW: 571.6 D
From 123.00€ *
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Bedaquiline Fumarate
Bedaquiline Fumarate

Item number: LKT-B165121.100

Bedaquiline is a diarylquinoline found to be useful in treating multidrug-resistant tuberculosis. In mouse models of TB, bedaquiline has significantly shortened the treatment regimen. A long-acting injectable formulation has been shown to have prolonged bactericidal activity. Bedaquiline inhibits ATP-synthase, and...
Keywords: (1R,2S)-1-(6-Bromo-2-methoxy-3-quinolinyl)-4-(dimethylamino)-2-(1-naphthyl)-1-phenyl-2-butanol (2E)-2-butenedioate (1:1)
Application: Antibacterial (tuberculostatic), ATP synthase inhibitor
CAS 845533-86-0
MW: 671.59 D
From 194.00€ *
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Camalexin
Camalexin

Item number: LKT-C016481.100

Camalexin is a phytoalexin found in various cruciferous plants after exposure to environmental stresses. Studies on acute myeloid leukemia cells show that camalexin selectively decreases cell viability. Several studies have already shown that exposure to camalexin causes cell shrinkage and phospholipid scrambling in...
Keywords: 3-(1,3-thiazol-2-yl)-1H-indole, 3-(thiazol-2-yl)indole, 2-(1H-indol-3-yl)-1,3-thiazole
Application: Bioactive phytoalexin
CAS 135531-86-1
MW: 200.26 D
From 84.00€ *
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LY-3214996
LY-3214996

Item number: LKT-L960012.100

LY-3214996 is a selective inhibitor of ERK1/2. ERK1/2 inhibitors offer a targeted approach to cancers in which the RAS/MAPK signaling pathway is dysregulated. These compounds can be successful when Braf and MEK inhibitor efficacy is lost due to developed drug resistance. LY-3214996 has demonstrated potent antitumor...
Keywords: LY 3214996, LY3214996, LY-3214996
Application: Selective ERK1/2 inhibitor
CAS 1951483-29-6
MW: 453.57 D
From 136.00€ *
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4-(Methylsulfinyl) butylamine
4-(Methylsulfinyl) butylamine

Item number: LKT-M185777.10

4-(Methylsulfinyl) butylamine is the synthetic precursor of sulforaphane.
Keywords: Schembl371434, CTK7E8172, 4-methanesulfinylbutan-1-amine, (+/-)-1-amino-4-(methylsulfinyl)butane,...
Application: Synthetic sulforaphane precursor
CAS 187587-70-8
MW: 135.23 D
From 58.00€ *
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L-(-)-Norepinephrine-(+)-bitartrate
L-(-)-Norepinephrine-(+)-bitartrate

Item number: LKT-N582686.1

Norepinephrine is a hormone and neurotransmitter that modulates sympathetic nervous system activity and plays a role in modulating reward, reinforcement, feeding, and other behaviors. Norepinephrine exhibits vasoconstrictive, pro-angiogenic, and thermoregulatory activities. Norepinephrine is clinically used to treat...
Keywords: L-(-)-Norepinephrine-(+)-bitartrate, 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol, 2,3-dihydroxybutanedioic acid,...
Application: Hormone, Neurotransmitter
CAS 69815-49-2
MW: 319.26 D
From 54.00€ *
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