Antibiotics

An antibiotic is a chemical substance that kills bacteria, protozoa or fungi or inhibits their proliferation. Due to this antimicrobial function antibiotics are used as therapeutics in case of bacterial infections. In life sciences, antibiotics are often used for selecting clones after transformation of recombinant DNA. This method uses resistance genes that are part of the transformed DNA. Alternatively Antibiotics are used as inhibitors to specifically shut down specific targets, like enzymes or receptors of bacteria and cells. Here you’ll find an extensive portfolio of antibiotics from ampicillin to zelkovamycin for use in the selection of resistant bacteria or inhibition of cells.

An antibiotic is a chemical substance that kills bacteria, protozoa or fungi or inhibits their proliferation. Due to this antimicrobial function antibiotics are used as therapeutics in case of... read more »
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Antibiotics

An antibiotic is a chemical substance that kills bacteria, protozoa or fungi or inhibits their proliferation. Due to this antimicrobial function antibiotics are used as therapeutics in case of bacterial infections. In life sciences, antibiotics are often used for selecting clones after transformation of recombinant DNA. This method uses resistance genes that are part of the transformed DNA. Alternatively Antibiotics are used as inhibitors to specifically shut down specific targets, like enzymes or receptors of bacteria and cells. Here you’ll find an extensive portfolio of antibiotics from ampicillin to zelkovamycin for use in the selection of resistant bacteria or inhibition of cells.

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Carbenicillin, disodium salt
Carbenicillin, disodium salt

Item number: 50195.5

Effective against gram-positive and gram-negative bacteria. It can be used in plant transformation for killing of Agrobacterium after co-cultivation with plant tissue.
Application: Antibiotic
CAS 4800-94-6
MW: 422.40
From 119.00€
Review
Ampicillin, sodium salt
Ampicillin, sodium salt

Item number: 01503.5

Crystalline, H2O: <2%, It is effective against gram-positive and some gram-negative bacteria, inhibiting cell wall synthesis.
Application: Antibiotic
CAS 69-52-3
MW: 371.39
From 23.00€
Review
Bafilomycin A1
Bafilomycin A1

Item number: Cay11038-500

Bafilomycin A1 is a selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases), blocking these proton pumps in mammalian, plant, or fungal cells with an IC50 value in the 4-400 nM range. It is at least 1,000-fold less potent at most other types of ATPases. Bafilomycin A1 also inhibits autophagy by preventing vacuolar acidification necessary for autophagosome maturation.
Application: V-ATPase inhibitor
CAS 88899-55-2
MW: 622.8 D
Purity: >95%
Format: Crystalline Solid
From 107.00€
Review
Anhydrotetracycline (hydrochloride)
Anhydrotetracycline (hydrochloride)

Item number: Cay10009542-100

The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression. Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription. Anhydrotetracycline...
Application: Antibiotic
CAS 13803-65-1
MW: 462.9 D
Purity: >98%
Format: Crystalline Solid
From 32.00€
Review
Tunicamycin
Tunicamycin

Item number: Cay11445-1

N-linked glycosylation is a highly regulated post-translational modification that is involved in protein folding and conformation, oligomerization, sorting, cell-cell interactions, and targeting of proteins to sub- or extra-cellular locations. It is initiated in the endoplastic reticulum with the transfer of a carbohydrate moiety to an asparagine residue within a specific...
Application: N-glycosylation inhibitor
CAS 11089-65-9
MW: 844.4 D
Purity: >95% (mixture of isomers)
Format: Crystalline Solid
From 33.00€
Review
Leptomycin B
Leptomycin B

Item number: Cay10004976-10

Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins. Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear export of mRNA-binding proteins (export factors). By blocking...
Application: Nuclear export blocker
CAS 87081-35-4
MW: 540.7 D
Purity: >98%
Format: Solution
From 35.00€
Review
Sulfasalazine
Sulfasalazine

Item number: Cay15025-5

Sulfasalazine is a prodrug of the anti-inflammatory agent 5-aminosalicylic acid that is covalently linked to the antibiotic sulfapyridine by an azo bond. This bond is rapidly cleaved by bacteria in the terminal ileum and colon, thus releasing the active anti-inflammatory component. It has long been used in treatment of inflammatory bowel disease and rheumatoid arthritis...
Application: Apoptosis inducer
CAS 599-79-1
MW: 398.4 D
Purity: >98%
Format: Crystalline Solid
From 32.00€
Review
Tigecycline
Tigecycline

Item number: Cay15026-5

Tigecycline is a glycylcycline antibiotic that binds to the bacterial 30S ribosome, blocking the entry of transfer RNA, which halts protein synthesis and thus limits bacterial growth. It has a broad spectrum of activity against many Gram-positive, Gram-negative, and anaerobic organisms, including many multidrug-resistant strains.
Application: Antibiotic, Protein synthesis inhibitor
CAS 220620-09-7
MW: 585.7 D
Purity: >98%
Format: Crystalline Solid
From 94.00€
Review
Kanamycin A (sulfate)
Kanamycin A (sulfate)

Item number: Cay15321-5

Kanamycin A is a broad spectrum antibiotic isolated from a soil streptomyces (S. kanamyceticus). This aminoglycoside alters translation by prokaryotic ribosomes, resulting in bacterial cell death. In molecular biology, kanamycin A is used as a selective agent to isolate transformants that are expressing a kanamycin resistance gene, usually neomycin phosphotransferase...
Application: Antibiotic
CAS 25389-94-0
MW: 582.6 D
Purity: >98%
Format: Crystalline Solid
From 49.00€
Review
Siomycin A
Siomycin A

Item number: Cay15378-500

The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Siomycin A is a peptide thiazole antibiotic, first isolated from S. sioyaensis, that interacts with the 23S rRNA of bacteria. It inhibits FoxM1 (IC50 = ~5 µM), preventing the expression of FoxM1-regulated genes, which includes FoxM1...
Application: FoxM1 expression inhibitor
CAS 12656-09-6
MW: 1648.9 D
Purity: >95%
Format: Solid
387.00€
Review
Bicyclomycin Benzoate
Bicyclomycin Benzoate

Item number: Cay15384-5

Bicyclomycin benzoate is an antibiotic produced by S. sapporonensis that inhibits Gram-negative bacteria, including E. coli, Klebsiella, Shigella, Salmonella, Citrobacter, E. cloacae, and the pathogenic group of Neisseria. It is inactive against Proteus, P. aeruginosa, and Gram-positive bacteria.
Application: Antibiotic
CAS 37134-40-0
MW: 406.4 D
Purity: >99%
Format: Solid
From 144.00€
Review
Ikarugamycin
Ikarugamycin

Item number: Cay15386-500

Ikarugamycin is a macrocyclic antibiotic first isolated from Streptomyces sp. that demonstrates potent antiprotozoal activity. It exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC50 = 221.3 nM in HL-60 cells) through genotoxicity and by inducing apoptosis and activation of caspases. It also was shown to significantly inhibit oxidized...
Application: Antibiotic
CAS 36531-78-9
MW: 478.6 D
Purity: >99%
Format: Solid
From 199.00€
Review
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