CpG Oligodeoxynucleotides

CpG Oligodeoxynucleotides (ODN) are small single-stranded DNA molecules containing CpG motifs. Their backbone is partially or completely phosphothioated. ODNs whose CpG motifs are unmethylated are recognized by pattern-recognition-receptors (PRR) like Toll-like Receptor 9 (TLR9) and act as immunostimulants. CpG Oligodeoxynucleotides induce cytokine and interferon production, B-cell and monocyte maturation and the activation of NK-cells and plasmocytoid dendritic cells. CpG Oligodeoxynucleotides are therefore used as adjuvants and in cancer therapy. ODNs containing a TTAGGG-motiv however are TLR9-Antagonists and have immunosuppressive effects.

CpG Oligodeoxynucleotides (ODN) are small single-stranded DNA molecules containing CpG motifs. Their backbone is partially or completely phosphothioated. ODNs whose CpG motifs are unmethylated are... read more »
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CpG Oligodeoxynucleotides

CpG Oligodeoxynucleotides (ODN) are small single-stranded DNA molecules containing CpG motifs. Their backbone is partially or completely phosphothioated. ODNs whose CpG motifs are unmethylated are recognized by pattern-recognition-receptors (PRR) like Toll-like Receptor 9 (TLR9) and act as immunostimulants. CpG Oligodeoxynucleotides induce cytokine and interferon production, B-cell and monocyte maturation and the activation of NK-cells and plasmocytoid dendritic cells. CpG Oligodeoxynucleotides are therefore used as adjuvants and in cancer therapy. ODNs containing a TTAGGG-motiv however are TLR9-Antagonists and have immunosuppressive effects.

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G-type iODN (inhibitory ODN) Endotoxin-free (sterile)
G-type iODN (inhibitory ODN) Endotoxin-free (sterile)

Item number: IAX-200-052-M001

Potent sequence of an inhibitory ODN of the poly-G class I targeting TLR9, but without effect on TLR7 and TLR8 signaling, for in vivo use in rodents (50-150 µg per injection). Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
Keywords: Inhibitory ODN (iODN): Class I
Application: TLR9 competitor
MW: 6735 D
From 98.00€ *
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ODN 2138 (Control for ODN 1826) Endotoxin-free (sterile)
ODN 2138 (Control for ODN 1826) Endotoxin-free (sterile)

Item number: IAX-200-201-C100

Negative control GpC ODN for in vivo use in rodents (50-150 µg per injection). As active compound use CpG ODN 1826 (Cat. No.: IAX-200-002). For negative control without agonistic nor antagonistic activity: Neutral-ODN (Cat. No.: IAX-200-202).
Application: Negative Control for ODN 1826 (IAX-200-002)
MW: 6383 D
98.00€ *
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Polyinosinic-polycytidylic acid [Poly(I:C)] Endotoxin-free (sterile)
Polyinosinic-polycytidylic acid [Poly(I:C)]...

Item number: IAX-200-021-M005

Activates TLR3, MDA5/Helicard and RIG-I. Optimal working concentration depends upon target receptor accessibility, number, density, as well as cell type, and therefore needs to be determined for each application. Recommended concentration range: in vitro: 0.5-10 µg/ml, in vivo: 5mg/kg.
Keywords: Polyinosinic-polycytidylic acid, potassium salt (poly (I:C))
Application: TLR3, MDA5/Helicard, RIG-I activator
From 112.00€ *
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ODN 1668 (Type B) Endotoxin-free (sterile)
ODN 1668 (Type B) Endotoxin-free (sterile)

Item number: IAX-200-001-M001

3 x 1 mg. Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 1720 (Cat. No.: IAX-200-200).
Keywords: CpG ODN TLR9 Agonist: B Type (species: rodent)
Application: TLR9 activator
MW: 6383 D
From 125.00€ *
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ODN M362 (Type C) Endotoxin-free (sterile)
ODN M362 (Type C) Endotoxin-free (sterile)

Item number: IAX-200-004-M001

Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 2243 (Cat. No.: IAX-200-205).
Keywords: CpG ODN TLR9 Agonist: A Type (species: human and rodent)
Application: TLR9 activator
MW: 6644 D
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ODN 1826 (Type B) Endotoxin-free (sterile)
ODN 1826 (Type B) Endotoxin-free (sterile)

Item number: IAX-200-002-M001

Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 1982 (Cat. No.: IAX-200-201).
Keywords: CpG ODN TLR9 Agonist: B Type (species: rodent)
Application: TLR9 activator
Reactivity: Mouse, Rat
MW: 6383 D
From 125.00€ *
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ODN 2006 (Type B) Endotoxin-free (sterile)
ODN 2006 (Type B) Endotoxin-free (sterile)

Item number: IAX-200-006-C100

3 x 1 mg. Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.7-7.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 2137 (Cat. No.: IAX-200-206).
Keywords: CpG ODN TLR9 Agonist: B Type (species: human and rodent)
Application: TLR9 activator
MW: 7720 D
From 125.00€ *
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ODN 1585 (Type A) Endotoxin-free (sterile)
ODN 1585 (Type A) Endotoxin-free (sterile)

Item number: IAX-200-003-M001

Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 2218 (Cat. No.: IAX-200-203). Unmethylated CG dinucleotides within particular sequence contexts are responsible for the...
Keywords: CpG ODN TLR9 Agonist: A Type (species: rodent)
Application: TLR9 activator
MW: 6643 D
From 125.00€ *
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ODN 2216 (Type A) Endotoxin-free (sterile)
ODN 2216 (Type A) Endotoxin-free (sterile)

Item number: IAX-200-005-C100

Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 2243 (Cat. No.: IAX-200-205).
Keywords: CpG ODN TLR9 Agonist: A Type (species: human and rodent)
Application: TLR9 activator
MW: 6644 D
From 125.00€ *
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iODN (inhibitory ODN) 2088 Endotoxin-free (sterile)
iODN (inhibitory ODN) 2088 Endotoxin-free (sterile)

Item number: IAX-200-050-3001

Potent sequence of an inhibitory ODN for in vivo use in rodents (50-150 µg per injection): prototype class I, may also affect TLR7 and TLR8 signaling. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
Keywords: Inhibitory ODN (iODN): Class I
Application: TLR9 competitor
MW: 4887 D
From 98.00€ *
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Neutral-ODN (Control for iODNs) Endotoxin-free (sterile)
Neutral-ODN (Control for iODNs) Endotoxin-free (sterile)

Item number: IAX-200-202-3001

3 x 1 mg. Negative control GpC ODN for in vivo use in rodents (50-150 µg per injection). As active compound use CpG ODN 1585 (Cat. No.: IAX-200-003). For negative control without agonistic nor antagonistic activity: Neutral-ODN (Cat. No.: IAX-200-202).
Application: Negative Control for ODN 1585 (IAX-200-003)
MW: 4821 D
From 98.00€ *
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ODN 2395 (Type C) Endotoxin-free (sterile)
ODN 2395 (Type C) Endotoxin-free (sterile)

Item number: IAX-200-007-C100

3 x 1 mg. Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.7-7.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
Keywords: CpG ODN: C Type (species: human and rodent)
Application: TLR9 activator
MW: 7068 D
From 125.00€ *
Review
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