CpG Oligodeoxynucleotides

CpG Oligodeoxynucleotides (ODN) are small single-stranded DNA molecules containing CpG motifs. Their backbone is partially or completely phosphothioated. ODNs whose CpG motifs are unmethylated are recognized by pattern-recognition-receptors (PRR) like Toll-like Receptor 9 (TLR9) and act as immunostimulants. CpG Oligodeoxynucleotides induce cytokine and interferon production, B-cell and monocyte maturation and the activation of NK-cells and plasmocytoid dendritic cells. CpG Oligodeoxynucleotides are therefore used as adjuvants and in cancer therapy. ODNs containing a TTAGGG-motiv however are TLR9-Antagonists and have immunosuppressive effects.

CpG Oligodeoxynucleotides (ODN) are small single-stranded DNA molecules containing CpG motifs. Their backbone is partially or completely phosphothioated. ODNs whose CpG motifs are unmethylated are... read more »
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CpG Oligodeoxynucleotides

CpG Oligodeoxynucleotides (ODN) are small single-stranded DNA molecules containing CpG motifs. Their backbone is partially or completely phosphothioated. ODNs whose CpG motifs are unmethylated are recognized by pattern-recognition-receptors (PRR) like Toll-like Receptor 9 (TLR9) and act as immunostimulants. CpG Oligodeoxynucleotides induce cytokine and interferon production, B-cell and monocyte maturation and the activation of NK-cells and plasmocytoid dendritic cells. CpG Oligodeoxynucleotides are therefore used as adjuvants and in cancer therapy. ODNs containing a TTAGGG-motiv however are TLR9-Antagonists and have immunosuppressive effects.

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ODN 1668 (Type B) Endotoxin-free (sterile)
ODN 1668 (Type B) Endotoxin-free (sterile)

Item number: IAX-200-001-M001

Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 1720 (Cat. No.: IAX-200-200).
Application: TLR9 activator
MW: 6383 D
Purity: >99.9%
Format: Purified
From 114.00€
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ODN 1826 (Type B) Endotoxin-free (sterile)
ODN 1826 (Type B) Endotoxin-free (sterile)

Item number: IAX-200-002-M001

Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 1982 (Cat. No.: IAX-200-201).
Application: TLR9 activator
Reactivity: Mouse, Rat
MW: 6383 D
Purity: >99.9%
Format: Purified
From 114.00€
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ODN 1585 (Type A) Endotoxin-free (sterile)
ODN 1585 (Type A) Endotoxin-free (sterile)

Item number: IAX-200-003-M001

Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 2218 (Cat. No.: IAX-200-203). Unmethylated CG dinucleotides within particular sequence contexts are responsible for the immunostimulatory activity of bacterial DNA. Synthetic...
Application: TLR9 activator
MW: 6643 D
Purity: >99.9%
Format: Purified
From 114.00€
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ODN M362 (Type C) Endotoxin-free (sterile)
ODN M362 (Type C) Endotoxin-free (sterile)

Item number: IAX-200-004-M001

Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 2243 (Cat. No.: IAX-200-205).
Application: TLR9 activator
MW: 6644 D
Purity: >99.9%
Format: Purified
From 114.00€
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ODN 2216 (Type A) Endotoxin-free (sterile)
ODN 2216 (Type A) Endotoxin-free (sterile)

Item number: IAX-200-005-M001

3 x 1 mg. Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.6-6.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 2243 (Cat. No.: IAX-200-205).
Application: TLR9 activator
MW: 6644 D
Purity: >99.9%
Format: Purified
From 114.00€
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ODN 2006 (Type B) Endotoxin-free (sterile)
ODN 2006 (Type B) Endotoxin-free (sterile)

Item number: IAX-200-006-M001

Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.7-7.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: GpC ODN 2137 (Cat. No.: IAX-200-206).
Application: TLR9 activator
MW: 7720 D
Purity: >99.9%
Format: Purified
From 114.00€
Review
iODN (inhibitory ODN) 2088 Endotoxin-free (sterile)
iODN (inhibitory ODN) 2088 Endotoxin-free...

Item number: IAX-200-050-M001

3 x 1 mg. Potent sequence of an inhibitory ODN for in vivo use in rodents (50-150 µg per injection): prototype class I, may also affect TLR7 and TLR8 signaling. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
Application: TLR9 competitor
MW: 4887 D
Format: Purified
From 89.00€
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iODN (inhibitory ODN) (ttaggg)4 Endotoxin-free (sterile)
iODN (inhibitory ODN) (ttaggg)4 Endotoxin-free...

Item number: IAX-200-051-M001

Potent sequence of an inhibitory ODN for in vivo use in rodents (100-300 µg per injection), prototype class II, inhibits STAT signaling, independent of TLR signaling. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
Application: STAT signaling inhibitor
MW: 8288 D
Format: Purified
From 89.00€
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G-type iODN (inhibitory ODN) Endotoxin-free (sterile)
G-type iODN (inhibitory ODN) Endotoxin-free...

Item number: IAX-200-052-M001

Potent sequence of an inhibitory ODN of the poly-G class I targeting TLR9, but without effect on TLR7 and TLR8 signaling, for in vivo use in rodents (50-150 µg per injection). Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
Application: TLR9 competitor
MW: 6735 D
Format: Purified
From 89.00€
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Mini-iODN (inhibitory ODN) Endotoxin-free (sterile)
Mini-iODN (inhibitory ODN) Endotoxin-free...

Item number: IAX-200-053-M001

Potent sequence of an inhibitory ODN for in vivo use in rodents (50-150 µg per injection): prototype class I, may also affect TLR7 and TLR8 signaling. egative control: Neutral-ODN (Cat. No.: IAX-200-202).
Application: TLR9 competitor
MW: 3584 D
Format: Purified
From 89.00€
Review
Mega-iODN (inhibitory ODN) Endotoxin-free (sterile)
Mega-iODN (inhibitory ODN) Endotoxin-free...

Item number: IAX-200-054-M001

Particularly potent sequence of an inhibitory ODN for in vivo use in rodents (50-150µg per injection): based on class I (ODN H154) and class II (ODN A151) sequences to combine inhibitory activity on TLRs and STAT signaling. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
Application: TLR9 competitor
MW: 5894 D
Format: Purified
From 89.00€
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Duo-iODN (inhibitory ODN) Endotoxin-free (sterile)
Duo-iODN (inhibitory ODN) Endotoxin-free (sterile)

Item number: IAX-200-055-M001

Potent sequence of an inhibitory ODN for in vivo use in rodents (50-150µg per injection): prototype class I that also inhibits TLR7 signaling. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
Application: TLR9 competitor
MW: 5867 D
Format: Purified
From 89.00€
Review
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