Products from Bethyl Laboratories
Bethyl Laboratories is based in Montgomery, Texas, USA. Bethyl's mission is to be the premier provider of polyclonal antibodies to the research market. Bethyl will do this by continuous identfication of new and emerging proteins of interest through collaborations and scholarly searches. Bethyl Labs is unique in their end-to-end control of the entire antibody lifecycle. From the veterinary facilities to the development, production and validation labs, the Bethyl team focuses on delivering quality products. This attention to quality at every step and the integration across each stage of the process means scientists can rely on Bethyl antibodies.
More information at: www.bethyl.com
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Anti-ASH2 Item number: A300-489A
Protein function: Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone...
| Keywords: | Anti-ASH2L, Anti-ASH2L1, Anti-ASH2-like protein, Anti-Set1/Ash2 histone methyltransferase complex subunit ASH2 |
| Application: | WB, IP, IHC, ChIP, ChIP-chip |
| Reactivity: | Human |
465.00€ *
Anti-NELFE Item number: A301-913A
Protein function: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. [The UniProt...
| Keywords: | Anti-RD, Anti-NELFE, Anti-NELF-E, Anti-RNA-binding protein RD, Anti-Negative elongation factor E |
| Application: | WB, IP |
| Reactivity: | Human |
From 131.00€ *
Anti-p73 Item number: A300-126A
Protein function: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. [The UniProt Consortium]
| Keywords: | Anti-P73, Anti-TP73, Anti-Tumor protein p73, Anti-p53-related protein, Anti-p53-like transcription factor |
| Application: | WB, IP |
| Reactivity: | Human |
From 131.00€ *
Anti-RbBP5 Item number: A300-109A
Protein function: In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. Component or...
| Keywords: | Anti-RBQ3, Anti-RBBP5, Anti-RBBP-5, Anti-Retinoblastoma-binding protein 5, Anti-Retinoblastoma-binding protein RBQ-3 |
| Application: | WB, IP, IHC, ICC, ChIP, ChIP-chip |
| Reactivity: | Human |
From 131.00€ *
Anti-HdmX/MDM4 Item number: A300-287A
Protein function: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. [The UniProt Consortium]
| Keywords: | Anti-MDM4, Anti-MDMX, Anti-Protein Mdm4, Anti-Protein Mdmx, Anti-Double minute 4 protein, Anti-p53-binding protein Mdm4,... |
| Application: | WB, IP |
| Reactivity: | Human |
From 131.00€ *
Anti-RBM9 (IHC) Item number: IHC-00199
Protein function: RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. RNA-binding protein that seems to...
| Keywords: | Anti-FOX2, Anti-RBFOX2, Anti-Fox-1 homolog B, Anti-RNA-binding protein 9, Anti-RNA-binding motif protein 9, Anti-RNA... |
| Application: | IHC |
| Reactivity: | Human, Mouse |
From 131.00€ *
Anti-SMARCC2/BAF170 (IHC) Item number: IHC-00213
Protein function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters...
| Keywords: | Anti-BAF170, Anti-SMARCC2, Anti-BRG1-associated factor 170, Anti-SWI/SNF complex 170 kDa subunit, Anti-SWI/SNF complex... |
| Application: | IHC |
| Reactivity: | Human, Mouse |
From 131.00€ *
Anti-MafA (IHC) Item number: IHC-00352
Protein function: Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Regulates the insulin gene transcription. Involved...
| Keywords: | Anti-Mafa, Anti-Transcription factor MafA, Anti-Pancreatic beta-cell-specific transcriptional activator, Anti-V-maf... |
| Application: | IHC |
| Reactivity: | Mouse |
From 131.00€ *
Anti-Ki-67 (IHC) Item number: IHC-00375
Protein function: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226)....
| Keywords: | Anti-Antigen Ki67 homolog, Anti-Antigen KI-67 homolog, Anti-Proliferation marker protein Ki-67, Anti-Antigen identified by... |
| Application: | IHC |
| Reactivity: | Mouse |
From 131.00€ *
Anti-ZEB1 (IHC) Item number: IHC-00419
Protein function: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by...
| Keywords: | Anti-ZEB1, Anti-AREB6, Anti-TCF-8, Anti-Transcription factor 8, Anti-Negative regulator of IL2, Anti-NIL-2-A zinc finger... |
| Application: | IHC |
| Reactivity: | Human, Mouse |
From 131.00€ *
Anti-BRG1/SMARCA4 (IHC) Item number: IHC-00466
Protein function: Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an...
| Keywords: | Anti-SMARCA4, Anti-BAF190A, Anti-SNF2-beta, EC=3.6.4.-, Anti-Protein BRG-1, Anti-Protein brahma homolog 1,... |
| Application: | IHC |
| Reactivity: | Human, Mouse |
From 131.00€ *
Anti-CASC5 (IHC) Item number: IHC-00500
Protein function: Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may...
| Keywords: | Anti-CT29, Anti-CASC5, Anti-Blinkin, Anti-AF15q14, Anti-KIAA1570, Anti-Protein CASC5, Anti-Protein D40/AF15q14,... |
| Application: | IHC |
| Reactivity: | Human |
From 131.00€ *