Anti-PIAS1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG41276.50	50 µg		-	-	6 - 14 business days*		520.00€

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Protein function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase,... more

Close menu

Product information "Anti-PIAS1"

Protein function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB. [The UniProt Consortium]

Keywords:	Anti-GBP, Anti-PIAS1, Anti-DDXBP1, EC=2.3.2.-, Anti-Gu-binding protein, Anti-DEAD/H box-binding protein 1, Anti-E3 SUMO-protein ligase PIAS1, Anti-RNA helicase II-binding protein, Anti-E3 SUMO-protein transferase PIAS1
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG41276

Properties

Application:	IHC (paraffin)
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, rat (Expected: mouse, hamster)
Immunogen:	Synthetic peptide corresponding to aa. 636-651 of Human PIAS1. (DTASIFGIIPDIISLD)
MW:	72 kD
Format:	Antigen Affinity Purified