Anti-NOX4

Anti-NOX4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F43447-0.08ML 80 µl - -

3 - 10 business days*

228.00€
NSJ-F43447-0.4ML 400 µl - -

3 - 10 business days*

549.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes a member of the NOX-family of... more
Product information "Anti-NOX4"
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants. Protein function: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity. [The UniProt Consortium]
Keywords: Anti-NOX4, Anti-KOX-1, Anti-RENOX, EC=1.6.3.-, Anti-NADPH oxidase 4, Anti-Kidney oxidase-1, Anti-Renal NAD(P)H-oxidase, Anti-Kidney superoxide-producing NADPH oxidase, NOX4 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F43447

Properties

Application: WB, IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: A portion of amino acids 124-153 from the human protein was used as the immunogen for this NOX4 antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow. more
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-NOX4"
Write a review
or to review a product.
Viewed