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Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-64074.60 60 µl - -

7 - 16 business days*

E-AB-64074.120 120 µl - -

7 - 16 business days*

E-AB-64074.200 200 µl - -

7 - 16 business days*

This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit... more
Product information "Anti-NOX4"
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants. Protein function: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity. [The UniProt Consortium]
Keywords: Anti-NOX4, Anti-RENOX, Anti-KOX-1, EC=1.6.3.-, Anti-NADPH oxidase 4, Anti-Kidney oxidase-1, Anti-Renal NAD(P)H-oxidase, Anti-Kidney superoxide-producing NADPH oxidase, NOX4 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-64074


Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Recombinant protein of human NOX4

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