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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
N5376-77B.100 | 100 µl | - | - |
3 - 19 business days* |
776.00€
|
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase,... more
Product information "Anti-NOX4 (NADPH Oxidase 4, NOX-4, Renal NAD(P)H-Oxidase, RENOX, Kidney Superoxide-producing NADPH o"
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggest that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2ug/ml, recognizes a band at ~67 kD, representing isoform 1. , immunohistochemistry 5 ug/ml , Optimal dilution determined by the researcher. Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | EC=1.6.3.-, Anti-NADPH oxidase 4, Anti-Kidney oxidase-1, Anti-Renal NAD(P)H-oxidase, Anti-Kidney superoxide-producing NADPH oxidase |
Supplier: | United States Biological |
Supplier-Nr: | N5376-77B |
Properties
Application: | IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | Biotin |
Host: | Rabbit |
Species reactivity: | bovine, human, monkey, mouse, rat, sheep |
Immunogen: | A synthetic peptide made to a region within residues 100-200 of the human NOX4 protein sequence. Cellular Localization: Endoplasmic reticulum, endoplasmic reticulum membrane, multi-pass membrane protein, cell membrane, nucleus (probable). |
Purity: | Purified by immunoaffinity chromatography. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K21423 | Matching products |
UniProt ID : | Q9NPH5 | Matching products |
Gene ID | GeneID 50507 | Matching products |
Handling & Safety
Storage: | +4°C (do not freeze) |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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