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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG52370.50 | 50 µl | - | - |
6 - 14 business days* |
592.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Component of NMDA receptor complexes that function as heterotetrameric,... more
Product information "Anti-phospho-NMDAR2B (Ser1480)"
Protein function: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1350383, PubMed:19910922, PubMed:21677647, PubMed:24876489, PubMed:27135925, PubMed:27916457). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity. [The UniProt Consortium]
Keywords: | Anti-phospho-NR2B, Anti-phospho-GluN2B, Anti-phospho-Grin2b, Anti-phospho-NMDAR2B, Anti-phospho-Glutamate receptor ionotropic, NMDA 2B, Anti-phospho-N-methyl D-aspartate receptor subtype 2B, Anti-phospho-Glutamate [NMDA] receptor subunit epsilon-2 |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG52370 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | rat (Expected: human, mouse, bovine, chicken, dog, primates, Xenopus laevis) |
Immunogen: | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1480 conjugated to KLH |
MW: | 166 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K05210 | Matching products |
UniProt ID : | Q00960 | Matching products |
Gene ID | GeneID 24410 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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