Anti-TRIM25

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG40744.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599).... more

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Product information "Anti-TRIM25"

Protein function: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1 (PubMed:17392790, PubMed:30193849). Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection (PubMed:17392790). Mediates 'Lys-63'-linked polyubiquitination of IFIH1 (PubMed:30193849). Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway (PubMed:16352599, PubMed:17069755). Mediates estrogen action in various target organs (PubMed:22452784). Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). [The UniProt Consortium]

Keywords:	Anti-TRIM25, Anti-Zinc finger protein 147, Anti-RING finger protein 147, Anti-E3 ubiquitin/ISG15 ligase TRIM25, Anti-RING-type E3 ubiquitin transferase, Anti-Estrogen-responsive finger protein, Anti-Tripartite motif-containing protein 25
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG40744

Properties

Application:	FC, ICC, IF, IHC (paraffin), IP, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Synthetic peptide derived from Human TRIM25
MW:	70 kD
Format:	Affinity Purified