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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-11-3041-25 | 25 µg | - |
3 - 11 business days* |
134.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Toll/interleukin-1 receptor-like protein (TLR1) is a member of the Toll-like receptor (TLR)... more
Product information "Anti-TLR1"
Toll/interleukin-1 receptor-like protein (TLR1) is a member of the Toll-like receptor (TLR) family which has close similarity to Drosophila Toll homologs. Toll receptors are involved in mediating dorsoventral polarization in the developing Drosophila embryo. TLR1 is a type I transmembrane receptor that characteristically contains an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLRs generally exist as homodimers but TLR6 forms heterodimers with TLR2 and binds lipopeptide components of gram-positive and gram-negative bacterial cell walls. TLR1 is found to be involved in ocular toxoplasmosis, and leprosy. It is highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. Protein function: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. [The UniProt Consortium]
Keywords: | Anti-TIL, Anti-TLR1, Anti-CD281, Anti-KIAA0012, Anti-Toll-like receptor 1, Anti-Toll/interleukin-1 receptor-like protein, Polyclonal Antibody to TLR1 |
Supplier: | Abeomics |
Supplier-Nr: | 11-3041-25 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | mouse, human |
Immunogen: | A partial length recombinant TLR1 protein (amino acids 300-500) was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K05398 | Matching products |
UniProt ID : | Q15399 | Matching products |
Gene ID | GeneID 7096 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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