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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay601800-1 | 1 each | - |
6 - 10 business days* |
621.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Prostaglandin F2alpha (PGF2alpha) is a biologically important prostanoid that exerts its actions... more
Product information "Prostaglandin F Receptor Reporter Assay Kit"
Prostaglandin F2alpha (PGF2alpha) is a biologically important prostanoid that exerts its actions through binding to the PGF2alpha receptor (FP). PGF2alpha is synthesized in many tissues, including the eye and organs of the female reproductive system. Activation of ocular FP receptors via agonists such as bimatoprost and travoprost reduces ocular hypertension. Antagonism of the FP receptor inhibits uterine contraction and delays parturition in rodent models, while knockout of the receptor inhibits parturition in mice, an effect that can be restored through ovariectomy during pregnancy. FP receptor antagonism also decreases endometriosis-like lesions and reduces cell proliferation and angiogenesis in a nude mouse endometrial xenograft model. In addition, FP receptor knockout increases neurological deficits and lesion volume in mice following intracerebral hemorrhagic stroke. These findings highlight the importance of the FP receptor in reproductive and neurological disorders and emphasize the need for continued research and drug discovery in these areas.Synonyms: FP, PGF2alpha Receptor, Prostglandin F2alpha Receptor, PTGFR.
Keywords: | FP, PGF2alpha Receptor, Prostglandin F2alpha Receptor, PTGFR |
Supplier: | Cayman Chemical |
Supplier-Nr: | 601800 |
Properties
Application: | Luminescent reporter assay |
Database Information
KEGG ID : | K04262 | Matching products |
UniProt ID : | P43088 | Matching products |
Gene ID | GeneID 5737 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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