56 products were found matching "K04262"!

Tafluprost is a prodrug form of the FP receptor agonist tafluprost (free acid) (Cay-10005439) and a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020). It decreases pupillary diameter in cats when applied topically at doses of 0.0001 or 0.001% v/v. Ocular administration of tafluprost (0.0005% v/v)...

Recombinant HEK293 cells stably overexpress human prostaglandin F receptor (PTGFR) on the surface and contain high level of G protein Galphaq to couple with the receptor in downstream signaling pathways.

AR-102-d4 is intended for use as an internal standard for the quantification of AR-102 (Cay9000362) by GC- or LC-MS. AR-102 is an FP receptor agonist, a derivative of prostaglandin F (PGF), and a prodrug form of AR-102 (free acid) (Cay10008049, Cay43439). SMILES...

The prostaglandin F2alpha receptor (FP receptor) is a G protein-coupled receptor known to elicit smooth muscle contraction in a variety of tissues. FP receptor mRNA is found in reproductive, gastric, neural, and ocular tissues as well as specialized cells of the kidney. Two FP receptor isoforms, FPA and FPB have...

An FP receptor agonist, a derivative of PGF, and a prodrug form of AR-102. Formulation: A solid. InChI: InChI=1S/C28H42O8S/c29-15-28(16-30,17-31)18-36-27(35)10-4-2-1-3-8-20-21(24(34)14-23(20)33)11-12-22(32)26-13-19-7-5-6-9-25(19)37-26/h5-7,9,13,20-24,29-34H,1-4,8,10-12,14-18H2/t20-,21-,22-,23+,24-/m1/s1. InChIKey:...

A derivative of AR-102 and AR-102 (free acid). Formulation: A solution in ethanol. InChI: InChI=1S/C26H38O5S/c1-17(2)31-26(30)12-6-4-3-5-10-19-20(23(29)16-22(19)28)13-14-21(27)25-15-18-9-7-8-11-24(18)32-25/h7-9,11,15,17,19-23,27-29H,3-6,10,12-14,16H2,1-2H3/t19-,20-,21-,22+,23-/m1/s1. InChIKey:...

BAY-6672 is an FP receptor antagonist (IC50 = 11 nM). It is selective for the FP receptor over the prostaglandin E2 (PGE2) receptor subtypes EP1, EP2, EP3, and EP4 (IC50s = >10, >10, >10, and >9. µM, respectively), as well as IP and DP receptors (IC50s = >10 µM for both). In vivo, BAY-6672 (30 mg/kg) reduces lung...

17-phenyl trinor Prostaglandin F2alpha (17-phenyl trinor PGF2alpha) is a metabolically stable analog of PGF2alpha and is a potent agonist for the FP receptor, binding with a relative potency of 756% compared to that of PGF2alpha. The ethyl amide of 17-phenyl trinor PGF2alpha bimatoprost has been approved for use as...

17-phenyl trinor Prostaglandin F2alpha (17-phenyl trinor PGF2alpha) is a metabolically stable analog of PGF2alpha and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2alpha. At the rat recombinant FP receptor expressed...

AL 8810 is an 11beta-fluoro analog of prostaglandin F2alpha (PGF2alpha) which acts as a potent and selective antagonist at the FP receptor. AL 8810 methyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as latanoprost...

Latanoprost is the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F2alpha. It is a prodrug of the free acid, which is a potent agonist of the FP receptor in the eye. Isopropyl 5-(diphenylphosphoryl)pentanoate is a potential trace impurity in commercial preparations of latanoprost.Formal Name:...

Protein function: Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum. Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling...