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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10009398-1 | 1 each | - |
6 - 10 business days* |
564.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
TPH catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of... more
Product information "Anti-Tryptophan Hydroxylase (Phospho-Ser260)"
TPH catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. TPH catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaM K II). CaM K II phosphorylate Ser260 which lies within the regulatory domain of TPH.Synonyms: TPH. Immunogen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser260 of rat tryptophan hydroxylase (TPH). Formulation: (Request formulation change), Peptide affinity-purified antibody. Host: Rabbit. Applications: WB. Origin: Animal/Rabbit.
Keywords: | TPH |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10009398 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | rat |
Immunogen: | phosphopeptide corresponding to amino acid residues surrounding phospho-Ser260 of rat tryptophan hydroxylase (TPH) |
Format: | Solid |
Database Information
KEGG ID : | K00502 | Matching products |
UniProt ID : | P09810 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H316, H319 |
P Phrases: | P264, P280, P305+351+338, P332+313, P337+313 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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