142 products were found matching "K00502"!

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. TPH2 antibody detects Tryptophan hydroxylase 2, encoded by the TPH2 gene. Tryptophan hydroxylase 2 is the rate limiting enzyme in the biosynthesis of serotonin in the brain. By catalyzing the...

Human tryptophan 5- hydroxylase 1 (TPH1) also known as TRPH, GenBank Accession No. NM_004179, a.a. 105-420 with an N-terminal His-tag, MW = 37 kDa, expressed in an E. coli cell expression system.

Human tryptophan hydroxylase 2 (TPH2) also known as neuronal tryptophan hydroxylase, GenBank Accession No. NM_173353, a.a. 151-466 (end) with an N-terminal His-tag, MW = 37 kDa, expressed in an E. coli cell expression system.

The TPH1 Assay Kit is designed to measure TPH1 enzyme inhibition in a 96 reaction format. This fluorescence-based assay kit is especially suitable for high throughput screening applications. The procedure is quick, straightforward, and simple just mix two solutions, incubate, add quenching solution, and measure the...

The TPH2 Assay Kit is designed to measure TPH2 enzyme inhibition in a 96 reaction format. This fluorescence-based assay kit is especially suitable for high throughput screening applications. The procedure is quick, straightforward, and simple just mix two solutions, incubate, add quenching solution, and measure the...

Telotristat etiprate is a prodrug form of telotristat, which is an inhibitor of tryptophan hydroxylase 1 (TPH1). Telotristat etiprate (15-300 mg/kg) reduces levels of serotonin (5-HT, Cay-14332) in mouse jejunum and blood but not brain. It inhibits increases in IL-1beta and IL-6 levels, histological damage in the...

Tryptophan is an amino acid precursor of serotonin (Cay-14332) and melatonin (Cay-14427). 6-fluoro-DL-Tryptophan is a serotonin synthesis inhibitor that is metabolized in the brain and may be useful for tracing pools of neuronal serotonin. It is used as a competitive inhibitor of tryptophan binding to albumin and...

Telotristat is a tryptophan hydroxylase 1 (TPH1) inhibitor (IC50 = 16 nM). Dietary administration of telotristat to pregnant and lactating mice decreases serotonin (5-HT, Cay-14332) levels in maternal serum and decreases the femoral bone volume to tissue volume ratio, trabecular number and thickness, and cortical...

p-chloro Phenylalanine is an inhibitor of tryptophan hydroxylase (Ki = 300 µM). It acts as a competitive inhibitor in vitro and an irreversible inhibitor in vivo. It depletes serotonin to undetectable levels in rats after six days when administered at a dose of 300 mg/kg. p-chloro Phenylalanine has commonly been...

Telotristat is the active metabolite of LX1606 (Telotristat etiprate), which is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.

Telotristat is the active metabolite of LX1606 (Telotristat etiprate), which is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.