Anti-phospho-SHP-2 (Tyr542)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABE-35-1287-50	50 µl		-		3 - 11 business days*		574.00€

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Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in... more

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Product information "Anti-phospho-SHP-2 (Tyr542)"

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Protein function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification. [The UniProt Consortium]

Keywords:	Anti-phospho-Shp2, Anti-phospho-PTP2C, Anti-phospho-SHP-2, Anti-phospho-PTP-1D, Anti-phospho-PTPN11, Anti-phospho-PTP-2C, Anti-phospho-SH-PTP3, Anti-phospho-SH-PTP2, Anti-phospho-Protein-tyrosine phosphatase 1D, Polyclonal Antibody to SHP-2 (Phospho-Tyr54
Supplier:	Abeomics
Supplier-Nr:	35-1287-50

Properties

Application:	WB, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Peptide sequence around phosphorylation site of tyrosine 542 (H-E-Y(p)-T-N) derived from Human SHP-2.
Format:	Purified