90 products were found matching "K07293"!

IACS-13909 is an allosteric inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2, IC50 = 11 nM). It binds wild-type SHP-2 and SHP-2 containing a constitutively activating glutamate-to-lysine substitution at position 76 (SHP-2E76K, Kds = 49 and 211 nM, respectively). IACS-13909 decreases the...

RMC-4630 is an allosteric inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2).Formal Name: 6-[(2-amino-3-chloro-4-pyridinyl)thio]-3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]dec-8-yl]-5-methyl-2-pyrazinemethanol. CAS Number: 2172652-48-9. Synonyms: SAR442720. Molecular Formula:...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat PTPN11. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PTPN11. Next,...

The Homogeneous full length SHP-2 Assay Kit is a complete assay system designed to measure full length SHP-2 activity for screening and profiling applications. Using this kit, only two simple steps on a microtiter plate are needed to analyze the full length SHP-2 activity level. At the first step, the SHP-2 enzyme...

SHP099 is an orally bioavailable inhibitor of SHP2, a non-receptor protein tyrosine phosphatase (IC50 = 71 nM). It stabilizes SHP2 in an auto-inhibited conformation. SHP099 suppresses signaling through the Ras-ERK pathway and blocks the proliferation of receptor tyrosine kinase-driven human cancer cells in vitro and...

IRS1_pY1172(dPEG8)pY1222(SEQ: H2N-LN(pY)IDLDLV(dPEG8)LST(pY) -ASINFQK-amide)

The Src homology region 2 domain-containing phosphatases (SHP) known as SHP-1 and SHP-2 act downstream of receptor and non-receptor tyrosine kinase to modulate signal transduction. NSC 87877 is a cell-permeable, inhibitor of both SHP-1 and SHP-2 (IC50 = 355 and 318 nM, respectively). It is much less effective...

Protein function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426). [The...

Human recombinant SHP-2, also known as PTPN11 (protein tyrosine phosphatase N11), catalytic domain, (a.a. 2-593 (end) with N-terminal His-tag, Genbank accession number NM_002834, MW=70 kDa, expressed in an E. coli expression system.

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TNO155 is an orally bioavailable allosteric inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2, IC50 = 0.011 µM). It is selective for SHP-2 over a panel of 52 kinases and phosphatases (IC50s = >10 µM for all). TNO155 decreases phosphorylation of ERK in, and inhibits proliferation of, KYSE-520...

Protein function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426). [The...