Anti-phospho-MDM2 (Ser166)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG51834.50	50 µl		-	-	6 - 14 business days*		436.00€
ARG51834.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading... more

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Product information "Anti-phospho-MDM2 (Ser166)"

Protein function: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. [The UniProt Consortium]

Keywords:	Anti-phospho-Hdm2, Anti-phospho-MDM2, EC=6.3.2.-, Anti-phospho-Oncoprotein Mdm2, Anti-phospho-Double minute 2 protein, Anti-phospho-p53-binding protein Mdm2, Anti-phospho-E3 ubiquitin-protein ligase Mdm2
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG51834

Properties

Application:	WB, IHC (paraffin), ICC, IF
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Peptide sequence around phosphorylation site of Serine 166 (A-I-S(p)-E-T) derived from Human MDM2
Format:	Affinity Purified