Anti-phospho-LIMK2 (Thr505)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABE-35-1123-50	50 µl		-		3 - 11 business days*		574.00€

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Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in... more

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Product information "Anti-phospho-LIMK2 (Thr505)"

Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Protein function: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways, phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). [The UniProt Consortium]

Keywords:	Anti-phospho-LIMK2, Anti-phospho-LIMK-2, Anti-phospho-LIM domain kinase 2, Polyclonal Antibody to LIMK2 (Phospho-Thr505)
Supplier:	Abeomics
Supplier-Nr:	35-1123-50

Properties

Application:	WB, IHC, IF
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Peptide sequence around phosphorylation site of threonine 505 (R-Y-T(p)-V-V) derived from Human LIMK2.
Format:	Purified