40 products were found matching "K05744"!

Rabbit Polyclonal LIMK2 Antibody against Human LIM domain kinase 2. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000020451: 95%, ENSRNOG00000019000:...

Soluble in DMSO. Kinases, such as LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2), have been identified as participating in signal pathways affecting actin dynamics by deactivating cofilin. Over expression of LMK1 has been found in invasive breast and prostate cancer cell lines and suppression of LIMK 2 expression has...

BMS-5 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 with IC50 values of 7 and 8 nM, respectively. LIMK1 and LIMK2 participate in signal pathways affecting actin dynamics by deactivating cofilin. This compound can be used to study the role of activated LIMK isoforms in the signaling of Rho...

Off-white solid. Soluble in DMSO (5mg/ml). Potent LIMK (Lim kinase) inhibitor. Has IC50 values of 5nM and 6nM for LIMK1 and LIMK2, respectively.

TH263 is an inactive analog of the inhibitor of LIM kinase 1 (LIMK1) and LIMK2 TH257 (Cay-34236) that has been used as a negative control for the kinase activity of LIMK1 and LIMK2.Formal Name: N-(phenylmethyl)-4-[[(phenylmethyl)amino]sulfonyl]-benzamide. CAS Number: 313520-94-4. Molecular Formula: C21H20N2O3S....

Description: TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM). Target: LIM Kinase. Smiles: CCCCN(Cc1ccccc1)C(=O)c1ccc(cc1)S(=O)(=O)Nc1ccccc1. References: Fabrizio M . Recent advances in the rational design and development of LIM kinase inhibitors are not enough...

Protein function: Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. [The UniProt Consortium]

0.5mg/ml if reconstituted with 0.2ml sterile DI water. LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene. There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc...

BMS-3 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 (IC50s = 5 and 6 nM, respectively). It is used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin and tubulin.Formal Name:...

LX7101 is a potent inhibitor of LIM kinase (LIMK) 1 and 2 and Rho-associated kinase 1 (ROCK1) and ROCK2 with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, showing no cross reactivity in a panel of binding assays including 78 receptors and transporters and 430 additional kinases, at a...

T5601640 is an inhibitor of LIM kinase 2 (LIMK2) that inhibits LIMK2-mediated cofilin phosphorylation. It reduces the levels of phosphorylated cofilin (p-cofilin) in mouse embryonic fibroblasts (MEF) lacking neurofibromin (Nf1-/-, IC50 = 30 µM), which normally have high levels of p-cofilin. T5601640 (50 µM)...

TH257 is an inhibitor of LIM kinase 1 (LIMK1) and LIMK2 (IC50s = 84 and 39 nM, respectively).Formal Name: N-butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)-benzamide. CAS Number: 2244678-29-1. Molecular Formula: C24H26N2O3S. Formula Weight: 422.5. Purity: >98%. Formulation: (Request formulation change), A solution...