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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
I7661-21M2.20 | 20 µl | - | - |
3 - 19 business days* |
462.00€
|
||
I7661-21M2.100 | 100 µl | - | - |
3 - 19 business days* |
834.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase... more
Product information "Anti-phospho-Insulin-Like Growth Factor I Receptor, beta, (Tyr1135) (IGF1Rb)"
Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues (1-3). Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) are the earliest major autophosphorylation sites (4). Phosphorylation of these three tyrosine residues is necessary for kinase activation (5,6). Insulin receptors (IRs) share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster (Tyr1146/1150/1151) within the kinase domain activation loop. Tyrosine auto-phosphorylation of the insulin receptor is one of the earliest cellular responses to insulin stimulation (7). Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation (8). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | EC=2.7.10.1, Anti-phospho-CD221, Anti-phospho-IGF-I receptor, Anti-phospho-Insulin-like growth factor 1 receptor, Anti-phospho-Insulin-like growth factor I receptor, Anti-phospho-Insulin-like growth factor 1 receptor beta chain |
Supplier: | United States Biological |
Supplier-Nr: | I7661-21M2 |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | 10E33(DA7A8) |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthetic phosphopeptide corresponding to residues surrounding Tyr1135 of human IGF-I receptor Beta (KLH-coupled). |
Format: | Purified |
Database Information
KEGG ID : | K05087 | Matching products |
UniProt ID : | P08069 | Matching products |
Gene ID | GeneID 3480 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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