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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay35906-100 | 100 µl | - | - |
6 - 10 business days* |
480.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
c-Jun N-terminal kinases (JNKs) are stress-activated serine/threonine protein kinases and members... more
Product information "Anti-JNK1/2/3 (Phospho-Thr183/Tyr185) Rabbit Monoclonal Antibody (Clone RM464)"
c-Jun N-terminal kinases (JNKs) are stress-activated serine/threonine protein kinases and members of the MAPK family with roles in cell proliferation, differentiation, apoptosis, and migration. JNKs are encoded by three distinct genes, JNK1, JNK2, and JNK3, which produce 10 variants via alternative splicing. JNK1 and JNK2 are ubiquitously expressed while JNK3 is expressed at high levels in the CNS and low levels in cardiac smooth muscle and the testis. In response to stress stimuli, such as osmotic or UV shock, cytokines, or growth factor signaling, JNKs are activated by phosphorylation at threonine 183 (Thr183) and tyrosine 185 (Tyr185) by MKK7 and MKK4, respectively, in a synergistic manner, and induce various transcription factor-mediated downstream signaling events. Neuronal levels of JNK (phospho- Thr183/Tyr185) are increased in mouse models of sporadic and prion-induced Alzheimer's disease. Renal JNK (phospho- Thr183/Tyr185) levels are increased in patients with glomerulonephritis and diabetic neuropathy and are associated with the degree of glomerulosclerosis and macrophage infiltration. Cayman's JNK1/2/3 (Phospho-Thr183/Tyr185) Rabbit Monoclonal Antibody (Clone RM464) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: c-Jun N-terminal Kinase. Immunogen: Peptide corresponding to human JNK1/2/3 (phospho-Thr183/Tyr185). Clone Designation: RM464. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) JNK1/2/3 (phospho-Thr183/Tyr185, (-) JNK1/2/3 without phosphorylation at Thr183/Tyr185.
Keywords: | Anti-phospho-JNK1, Anti-phospho-MAPK8, Anti-phospho-JNK-46, Anti-phospho-SAPK1c, Anti-phospho-MAPK 8, Anti-phospho-MAP kinase 8, Anti-phospho-c-Jun N-terminal kinase 1, Anti-phospho-Stress-activated protein kinase 1c |
Supplier: | Cayman Chemical |
Supplier-Nr: | 35906 |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | RM464 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Peptide corresponding to human JNK1/2/3 (phospho-Thr183/Tyr185) |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04440 | Matching products |
UniProt ID : | P45983 | Matching products |
Gene ID | GeneID 5599 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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