245 products were found matching "K04440"!

SR 3306 is a pan-JNK inhibitor (IC50s = 67, 283, and 159 nM for JNK1, JNK2, and JNK3, respectively). It is selective for JNK1-3 over p38 MAPK (IC50 = >20 µM). SR 3306 (300-1,000 nM) reduces cell death induced by N-methyl-4-phenylpyridinium (MPP+) in primary rat mesencephalic dopaminergic neurons. It reduces MPTP- or...

Description: JNK1 Protein, Human, Recombinant (His) is expressed in Baculovirus Insect Cells with N-6xHis. The accession number is P45983.

IQ-3 is a JNK inhibitor. It is selective for JNKs over a panel of 131 kinases at 10 µM. IQ-3 binds to JNKs (Kd = 0. 0. and 0. µM for JNK1-3), as well as casein kinase 1delta (CK1delta), PI3Kgamma, and MAPK-interacting serine/threonine kinase 2 (MKNK2. Kds = 0. 0. and 1. µM, respectively). It also inhibits...

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by...

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific...

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA.

SP6000125 is a pan-inhibitor of JNK (IC50s = 0.04, 0.04, and 0.09 µM for JNK1, -2, and -3, respectively). It is greater than 300-fold selective for these enzymes over a panel of 17 additional kinases at 10 µM. SP6000125 reduces LPS-induced production of IL-1beta, IL-8, and TNF-alpha in isolated human peripheral...

Description: Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity. Target: JNK. Smiles: Cl.OC1CCC(CC1)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@H]3CCOC3)c2n1. References: Plantevin Krenitsky V, et al. Discovery of CC-930, an orally active...

Protein function: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress- activated protein kinase/c-Jun N-terminal...

Protein function: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress- activated protein kinase/c-Jun N-terminal...

JNK inhibitor VIII is an inhibitor of JNK1, JNK2, and JNK3 (Kis= 2, 4, and 52 nM, respectively). It is selective for JNK1, JNK2, and JNK3 over a panel of 74 kinases (Kis = >720 nM for all). It inhibits the phosphorylation of c-Jun in HepG2 cells (EC50 = 920 nM). JNK inhibitor VIII (10 µM) inhibits NGF-induced...

CC-930 is an orally bioavailable and potent inhibitor of JNKs (IC50s = 61, 7, and 6 nM for JNK1, JNK2, and JNK3, respectively). It is selective for MAP kinases over a panel of 240 kinases, showing greater than 50% inhibition at only one non-MAP kinase target, EGFR (IC50 = 380 nM). Within the MAPK family, it is...