Anti-GSK3beta (Phospho-Ser9)

Glycogen synthase kinase 3beta (GSK3beta) is a serine/threonine protein kinase that has roles in numerous signaling pathways and cellular processes, including cell proliferation and survival, as well as neural development and plasticity. It is composed of an N-terminal beta-strand domain, a kinase domain, and a C-terminal alpha-helical domain. GSK3beta is constitutively active, ubiquitously expressed, and localizes predominantly to the cytosol but is also found in the nucleus and mitochondria. It is inhibited by phosphorylation at serine 9 (Ser9), which is mediated by a variety of kinases, including PKA, PKB, and Akt, and has roles in insulin, growth factor, and Wnt signaling pathways. GSK3beta is involved in several pathophysiological conditions, such as diabetes, cancer, inflammation, and neurological or psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and bipolar disorder. Levels of GSK3beta (phospho-Ser9) are decreased in the hippocampus and prefrontal cortex in a rat model of memory impairment and are rescued by lithium. The overexpression of GSK3beta with low levels of Ser9 phosphorylation is associated with a poor prognosis in patients with pancreatic ductal carcinoma (PDAC). However, GSK3beta (phospho-Ser9) levels are increased in cisplatin-resistant ovarian cancer cells in vitro and in skin cancer tissues from patients with squamous cell carcinoma. Cayman's GSK3beta (Phospho-Ser9) Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes GSK3beta (phospho-Ser9) at ~46 kDa from rat and mouse samples.Synonyms: Glycogen Synthase Kinase 3beta, GSK3B, Serine/threonine-protein Kinase GSK3B. Immunogen: Phosphopeptide corresponding to rat GSK3beta (phospho-Ser9). MW: ~46 kDa. Formulation: (Request formulation change), Peptide affinity-purified antibody. Storage Buffer: 10 mM HEPES, pH 7.5, with 150 nM sodium chloride, 100 µg BSA, and 50% glycerol. Host: Rabbit. Applications: WB. Cross Reactivity: (+) GSK3beta. UniProt Accession #: P18266. Origin: Animal/Rabbit.