156 products were found matching "K03083"!

CHIR99021 is an aminopyrimidine derivative that inhibits GSK3alpha and GSK3beta with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.763...

WIC1 is an inhibitor of Wnt signaling. It inhibits Wnt signaling induced by the glycogen synthase kinase 3beta (GSK3beta) inhibitor CHIR99021 (Cay-13122) in a reporter assay using BEAS-2B cells when used at a concentration of 100 nM. WIC1 (1 µM) induces differentiation of, and decreases CHIR99021-induced...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse GSK3b. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse GSK3b. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GSK3b. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human GSK3b. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat GSK3b. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat GSK3b. Next,...

Glycogen synthase kinase 3 beta, also known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene. Protein function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and...

CHIR99021 is an aminopyrimidine derivative that inhibits GSK3alpha and GSK3beta with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.763...

Protein function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC,...

Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli including insulin, growth factors, cell specification factors, and cell adhesion. SB-216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3alpha with an IC50...

Manzamine A is a beta-carboline alkaloid with diverse activities that has been found in marine sponges, including X. ashmorica. It is an inhibitor of glycogen synthase kinase 3beta (GSK3beta) and cyclin-dependent kinase 5 (CDK5, IC50s = 10.2 and 1.5 µM, respectively). It inhibits the growth of L5178y mouse lymphoma...

Active human GSK3beta GenBank Accession No. NM_002093), full length, with N-terminal GST tag, MW=73 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose...