191 products were found matching "K03083"!

CHIR99021 is an aminopyrimidine derivative that inhibits GSK3alpha and GSK3beta with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.763...

GSK3beta inhibitor XIII is an inhibitor of glycogen synthase kinase beta (GSK3beta, IC50 = 0.73 nM). It is selective for GSK3beta over cyclin-dependent kinase 2 (Cdk2), Cdk5, AP2-associated protein kinase 1 (AAK1), Pim-1, and PKCtheta (IC50s = 1.4, 6.4, 0.2, 0.38, and 0.36 µM, respectively) and a panel of 30...

The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice...

Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli including insulin, growth factors, cell specification factors, and cell adhesion. SB-216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3alpha with an IC50...

Active human GSK3beta GenBank Accession No. NM_002093), full length, with N-terminal GST tag, MW=73 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3alpha/beta (IC50 = 5 nM). Its specificity has been tested against various cyclin-dependent kinases (CDKs) (IC50s = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A,...

The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice...

Indirubin-3'-oxime is a potent inhibitor of glycogen synthase kinase 3beta (GSK3beta, IC50 = 22 nM). As GSK3beta phosphorylates tau protein, indirubin-3'-oxime prevents tau phosphorylation both in vitro and in vivo at Alzheimer's disease-relevant sites. It also inhibits cyclin-dependent kinases (CDKs) at higher...

1-Azakenpaullone is an analog of kenpaullone (Cay-10010239) that inhibits glycogen synthase kinase 3beta (GSK3beta) more potently (IC50 = 18 nM) than CDK1/cyclin B or CDK5/p25 (IC50s = 2.0 and 4.2 µM, respectively). Through its effects on GSK3beta, 1-azakenpaullone stimulates the proliferation of human pancreatic...

Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by a number of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including cell division, apoptosis, and inflammation. TWS119 is a...

Potent and ATP-competitive GSK-3beta (glycogen synthase kinase-3beta) inhibitor (IC50 = 18 nM).

Alsterpaullone is a derivative of kenpaullone (Cay-10010239), an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3beta (GSK3beta). With slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E,...