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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
B0807-02D.1 | 1 kit | - | - |
3 - 19 business days* |
991.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The Bcl-2 family consists of a number of evolutionarily conserved proteins containing Bcl-2... more
Product information "Bcl 2 (B Cell Leukemia 2), Pro-Survival Family Antibody Sampler Kit, BioAssay (Human Specific)"
The Bcl-2 family consists of a number of evolutionarily conserved proteins containing Bcl-2 homology domains (BH) that regulate apoptosis through control of mitochondrial membrane permeability and release of cytochrome c (1-3). Four BH domains have been identified (BH1-4), which mediate protein interactions. The family can be separated into three groups based upon function and sequence homology: pro-surivival members including Bcl-2, Bcl-xL, Mcl-1, A1, and Bcl-w, pro-apoptotic proteins including Bax, Bak, and Bok, and "BH3 only" proteins Bad, Bik, Bid, Puma, Bim, Bmf, Noxa, and Hrk. Interactions between death-promoting, and death-suppressing Bcl-2 family members has led to a rheostat model in which the ratio of pro-apoptotic and anti-apoptotic proteins controls cell fate (4). Thus, pro-survival members exert their behavior by binding to and antagonizing death-promoting members. In general, the "BH3-only members" can bind to and antagonize the pro-survival proteins leading to, increased apoptosis (5). While some redundancy of this system likely exists, tissue specificity and transcriptional and post-translational regulation of many of these family members can account for distinct physiological roles. Several phosphorylation sites have been identified within, Bcl-2 including Thr56, Ser70, Thr74, and Ser87 (6). Included antibodies: B0807-02D1 Bcl 2, phosphorylated (Ser70) 20ul W, F H 28kD Rabbit, B0807-02D2 Bcl-2, phosphorylated (Thr56) 20ul W H 28kD Rabbit, B0807-02D3 Bcl-2 20ul W, IP, IHC H 28kD Rabbit, B0807-02D4 Bcl-XL 20ul W, IP, IHC H, M, R, Mk 30kD Rabbit, B0807-02D5 Mcl-1 20ul W H 40kD Rabbit, B0807-02D6 IgG (HRP) 100ul Goat, Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot. Freeze at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-BCL2, Anti-Apoptosis regulator Bcl-2 |
Supplier: | United States Biological |
Supplier-Nr: | B0807-02D |
Properties
Application: | WB |
Conjugate: | No |
Species reactivity: | human |
Format: | Affinity Purified |
Database Information
KEGG ID : | K02161 | Matching products |
UniProt ID : | P10415 | Matching products |
Gene ID | GeneID 596 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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