The following products have been found matching your search "K02161": 245

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ABT-263
ABT-263

Item number: Cay11500-10

The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with...
Keywords: A-855071, Navitoclax,...
Application: Potent, cell-permeable BH3 domain mimetic
CAS 923564-51-6
MW: 974.6 D
From 44.00€ *
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ABT-199
ABT-199

Item number: Cay16233-25

B-cell lymphoma/leukemia 2 (Bcl-2) is an anti-apoptotic protein that controls cell survival by binding the BH3 domains of pro-death BAD and BAK proteins and preventing permeabilization of the mitochondrial outer membrane. This protein is tightly regulated for the homeostasis between cell growth and cell death. The...
Keywords: GDC 0199,...
Application: BCL-2 inhibitor
CAS 1257044-40-8
MW: 868.4 D
From 37.00€ *
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ABT-199
ABT-199

Item number: LKT-A0776.5

ABT-199 is a BH3 mimetic that inhibits Bcl-2 but does not affect Bcl-xl. ABT-199 exhibits anticancer chemotherapeutic activity, inducing Bim-mediated apoptosis in chronic lymphocytic leukemia (CLL) cells. ABT-199 also induces cell death and inhibits tumor growth in acute myelogenous leukemia (AML) models in vitro,...
Keywords: GDC-0199
Application: BH3 mimetic, Bcl-2 inhibitor
CAS 1257044-40-8
MW: 868.44 D
From 82.00€ *
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ABT-737
ABT-737

Item number: Cay11501-25

The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with...
Keywords: 4-[4-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]am...
Application: Potent, cell-permeable BH3 domain mimetic
CAS 852808-04-9
MW: 813.4 D
From 82.00€ *
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Obatoclax (mesylate)
Obatoclax (mesylate)

Item number: Cay11499-1

Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM). It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and...
Keywords: GX15-070, 2-[2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole, monomethanesulfonate
Application: Antagonist of Bcl-2 family members containing four Bcl-2 homology domains
CAS 803712-79-0
MW: 413.5 D
From 62.00€ *
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ABT-737
ABT-737

Item number: SYN-1001-M001

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate...
Keywords: ABT737
Application: Bcl-2 / Bcl-X(L) / Bcl-w inhibitor
CAS 852808-04-9
MW: 813,4 D
From 79.00€ *
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Venetoclax, Free Base (ABT-199, GDC-0199, CAS 1257044-40-8), >99%
Venetoclax, Free Base (ABT-199, GDC-0199, CAS...

Item number: LC-V-3579_25mg

Soluble in DMSO
Keywords: GDC 0199,...
Application: BCL-2 inhibitor
CAS 1257044-40-8
MW: 868,44 D
From 72.00€ *
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TW-37
TW-37

Item number: Cay20999-5

TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively). It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells. TW-37 decreases the density of...
Keywords: N-[4-[[2-(1,1-dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]-benzamide
Application: Bcl-2 / Mcl-1 / Bcl-xL inhibitor
CAS 877877-35-5
MW: 573.7 D
From 112.00€ *
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BCL2, Human B-cell CLL/lymphoma 2, Real Time PCR Primer Set
BCL2, Human B-cell CLL/lymphoma 2, Real Time PCR Primer Set

Item number: VHPS-10345

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....
Keywords: BCL2, Apoptosis regulator Bcl-2
Application: RNA quantification
45.00€ *
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Gossypol
Gossypol

Item number: LKT-G5874.25

A potential male anti-fertility agent from cotton that exhibits a wide spectrum of toxicity. It was found to have cytotoxic effects on human cancer cell lines. It is a potent telomerase inhibitor.
Application: Telomerase inhibitor
CAS 303-45-7
MW: 518,55 D
From 71.00€ *
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Gambogic Acid
Gambogic Acid

Item number: Cay14761-1

Gambogic acid (GA) is a natural product isolated from the G. hanburyi tree that exhibits anti-cancer activity by acting on a variety of cellular pathways. In the apoptotic pathway, GA activates caspases (EC50 = 0.78 µM), inhibits binding of anti-apoptotic proteins to a BH3 peptide (IC50 = 1.47, 1.21, 2.02, 0.66,...
Keywords: GA, beta-Guttiferin,...
Application: Caspase activator
CAS 2752-65-0
MW: 628.8 D
From 33.00€ *
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HA-14-1
HA-14-1

Item number: Cay14876-5

HA-14-1 is a small molecule that binds the surface pocket of Bcl-2 proteins (IC50 = ~ 9 µM) and induces apoptosis by interfering with its interaction with the Bak peptide and activating Apaf-1 and caspase-9 and -3. It can also bind to the antiapoptotic Bcl-2 proteins Bcl-xl and Bcl-W. HA-14-1 has been shown to...
Keywords: (alphaR,4R)-rel-2-amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid, ethyl ester
Application: Apoptosis inducer
CAS 927635-64-1
MW: 409.2 D
From 32.00€ *
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