Anti-USP22

USP22 (Ubiquitin Specific Peptidase 22) is a Protein Coding gene. Diseases associated with USP22 include Glandular Tularemia and Typhoidal Tularemia. Among its related pathways are Chromatin organization and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include enzyme binding and cysteine-type endopeptidase activity. An important paralog of this gene is USP51. Protein function: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression. [The UniProt Consortium]