Anti-USP22, CT (Ubiquitin Carboxyl-terminal Hydrolase 22, Ubiquitin Thiolesterase 22, Ubiquitin-spec

Anti-USP22, CT (Ubiquitin Carboxyl-terminal Hydrolase 22, Ubiquitin Thiolesterase 22, Ubiquitin-spec
Item number Size Datasheet Manual SDS Delivery time Quantity Price
U4101-07A.200 200 µl - -

3 - 19 business days*

728.00€
 
Modification of target proteins by ubiquitin participates in a wide array of biological... more
Product information "Anti-USP22, CT (Ubiquitin Carboxyl-terminal Hydrolase 22, Ubiquitin Thiolesterase 22, Ubiquitin-spec"
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions. Applications: Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-1:500, Immunohistochemistry: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: EC=3.4.19.12, Anti-Ubiquitin thioesterase 22, Anti-Deubiquitinating enzyme 22, Anti-Ubiquitin carboxyl-terminal hydrolase 22, Anti-Ubiquitin-specific-processing protease 22
Supplier: United States Biological
Supplier-Nr: U4101-07A

Properties

Application: ELISA, IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Synthetic peptide selected from the C-terminal region of human USP22 (KLH).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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