Anti-USP20/VDU2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A301-189A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A301-189A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2)... more

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Product information "Anti-USP20/VDU2"

Protein function: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. [The UniProt Consortium]

Keywords:	Anti-hVDU2, Anti-USP20, Anti-KIAA1003, EC=3.4.19.12, Anti-Ubiquitin thioesterase 20, Anti-Deubiquitinating enzyme 20, Anti-Ubiquitin carboxyl-terminal hydrolase 20, Anti-VHL-interacting deubiquitinating enzyme 2
Supplier:	Bethyl Laboratories
Supplier-Nr:	A301-189A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: chicken, dog, horse, rabbit, pig, panda, orangutan, rhesus monkey, gorilla, chimpanzee, tasmanian devil, white-tufted-ear marmoset, crab-eating macaque, african elephant, chinese hamster, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A301-189A-T maps to a region between residue 863 and 913 of human ubiquitin specific peptidase 20 (pVHL-interacting deubiquitinating enzyme 2) using the numbering given in entry NP_006667.2 (GeneID 10868).
Format:	Antigen Affinity Purified