Anti-UBE1

Anti-UBE1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-128A-T 10 µl (2 µg) -

2 - 8 business days*

164.00€
A301-128A 100 µl -

2 - 8 business days*

588.00€
 
Protein function: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for... more
Product information "Anti-UBE1"
Protein function: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation- induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334). [The UniProt Consortium]
Keywords: Anti-UBA1, Anti-A1S9T, Anti-Protein A1S9, Anti-Ubiquitin-activating enzyme E1, Anti-Ubiquitin-like modifier-activating enzyme 1
Supplier: Bethyl Laboratories
Supplier-Nr: A301-128A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, bovine, rabbit)
Immunogen: synthetic peptide. The epitope recognized by A301-128A-T maps to a region between residue 1008 and 1058 of human ubiquitin-activating enzyme E1 using the numbering given in entry NP_003325.2 (GeneID 7317).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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