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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-36-3308-20 | 20 µg | - |
3 - 11 business days* |
375.00€
|
|||
ABE-36-3308-100 | 100 µg | - |
3 - 11 business days* |
853.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Tryptases comprise a family of trypsin-like serine proteases (peptidase family S1). Tryptases are... more
Product information "Anti-Tryptase (Mast Cell Marker) Monoclonal Antibody (Clone: TPSAB1/1961)"
Tryptases comprise a family of trypsin-like serine proteases (peptidase family S1). Tryptases are stored in mast cell secretory granules and basophils. Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Tryptases are released into the extracellular environment and are resistant to all known endogenous proteinase inhibitors. This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis. Protein function: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315). [The UniProt Consortium]
Keywords: | Anti-TPS1, Anti-TPSAB1, Anti-Tryptase-1, Anti-Tryptase I, EC=3.4.21.59, Anti-Tryptase alpha-1, Anti-Tryptase alpha/beta-1, Anti-Tryptase (Mast Cell Marker) Monoclonal Antibody (Clone: TPSAB1/1961) |
Supplier: | Abeomics |
Supplier-Nr: | 36-3308 |
Properties
Application: | IHC |
Antibody Type: | Monoclonal |
Clone: | TPSAB1/1961 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant human Tryptase protein fragment (around aa 115-233) (Exact sequence is proprietary) |
Database Information
KEGG ID : | K01340 | Matching products |
UniProt ID : | Q15661 | Matching products |
Gene ID | GeneID 7177 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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