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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES9245.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES9245.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain... more
Product information "Anti-TNIK"
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008], Protein function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N- terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Keywords: | Anti-TNIK, Anti-KIAA0551, EC=2.7.11.1, Anti-TRAF2 and NCK-interacting protein kinase, TNIK rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES9245 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Synthesized peptide derived from human protein . at AA range: 350-430 |
MW: | 149 kD |
Format: | Purified |
Database Information
KEGG ID : | K08840 | Matching products |
UniProt ID : | Q9UKE5 | Matching products |
Gene ID | GeneID 23043 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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