24 products were found matching "K08840"!

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TNIK antibody detects Traf2 and Nck-interacting kinase, encoded by the TNIK gene on chromosome 3q26.32. TNIK antibody is widely used to study this serine/threonine kinase of the germinal center kinase family, which integrates multiple...

NPC-0846 is an inhibitor of TRAF2- and NCK-interacting kinase (TNIK, IC50 = 21 nM). It is selective for TNIK over a panel of 46 kinases but does inhibit FLT3, JAK3, PDGFRalpha, TrkA, Cdk2/CycA2, and HGK by greater than 80% at 100 nM. NPC-0845 (3 µM) inhibits phosphorylation of transcription factor 4 (TCF4) and...

Recombinant human TNIK (TRAF2 and NCK interacting kinase), encompassing amino acids, 2-325. This construct contains an N-Terminal GST-tag. A short peptide linker placed between GST and the protein includes a Thrombin Cleavage Site to facilitate removal of the GST portion. The recombinant protein was affinity purified.

Protein function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the...

Protein function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the...

KY 05009 is an inhibitor of TRAF2- and NCK-interacting kinase (TNIK, Ki = 100 nM). It inhibits TGF-beta1-induced Wnt, NF-kappaB, ERK, and JNK signaling and prevents TGF-beta1-induced epithelial-to-mesenchymal transition (EMT) in A549 lung cancer cells without inducing cytotoxicity when used at a concentration of 10...

Protein function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N- terminal pathway. May play a role in the...

Protein function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N- terminal pathway. May play a role in the...

Description: NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM). Target: Wnt/beta-catenin, MAPK. Smiles: O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3ccc4nc[nH]c4c3)nc12. References: Masuda M, et al. TNIK inhibition abrogates colorectal cancer stemness. Nat Commun. 2016 Aug 26,7:12586.

Make to order. Production time: 70-80 business days. Deliverables: 1. 200 µg antigen (used as positive control), 2. 1 ml pre-immune serum (used as negative control) , 3. Rabbit polyclonal antibody, antigen affinity purified. Quality Guarantee: 1. Antibody purity > 90% confirmed by SDS-PAGE, 2. Antibody titer > 1:...

Protein function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N- terminal pathway. May play a role in the...

Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM], Applications: Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not...