24 products were found matching "K08840"!

NPC-0846 is an inhibitor of TRAF2- and NCK-interacting kinase (TNIK, IC50 = 21 nM). It is selective for TNIK over a panel of 46 kinases but does inhibit FLT3, JAK3, PDGFRalpha, TrkA, Cdk2/CycA2, and HGK by greater than 80% at 100 nM. NPC-0845 (3 µM) inhibits phosphorylation of transcription factor 4 (TCF4) and...

Protein function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the...

Protein function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the...

KY 05009 is an inhibitor of TRAF2- and NCK-interacting kinase (TNIK, Ki = 100 nM). It inhibits TGF-beta1-induced Wnt, NF-kappaB, ERK, and JNK signaling and prevents TGF-beta1-induced epithelial-to-mesenchymal transition (EMT) in A549 lung cancer cells without inducing cytotoxicity when used at a concentration of 10...

Protein function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N- terminal pathway. May play a role in the...

Protein function: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N- terminal pathway. May play a role in the...

The TNIK Kinase Assay Kit is designed to measure TNIK kinase activity for screening and profiling applications using Kinase-Glo(R) MAX as a detection reagent.

Recombinant human TNIK (TRAF2 and NCK interacting kinase), encompassing amino acids, 2-325. This construct contains an N-Terminal GST-tag. A short peptide linker placed between GST and the protein includes a Thrombin Cleavage Site to facilitate removal of the GST portion. The recombinant protein was affinity purified.

Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008], Protein function: Serine/threonine kinase that acts as an essential activator of the Wnt...

Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM], Applications: Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not...

Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM], Applications: Suitable for use in FLISA and Immunohistochemistry. Other applications not tested....

Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM], Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested....