Anti-SNRPN (Sm protein D)

SNRPN(Small Nuclear Ribonucleoprotein Polypeptide N), also called SMN, is a bicistronic imprinted , gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and , the SNRPN upstream reading frame (SNURF) polypeptide. The protein encoded by this gene is one , polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family., SNRPN also encodes a long alternatively spliced transcript containing several small nucleolar RNAs , (snoRNAs) and extends downstream to partially overlap the UBE3A gene in the antisense orientation. , PWS arises from loss of function of genes in this region expressed exclusively from the paternal , chromosome, suggesting that SNRPN may play a role in its etiology. The SNRPN gene is mapped , on 15q11.2. Analysis of maternal DNA and of SNRPN cDNA confirmed that the maternal allele is not , expressed in fetal brain and heart. Deletions in the transcription unit of the imprinted SNRPN gene , occur in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in , this chromosomal domain. UniProt Number: P63162, Gene ID: SNRPN, Applications: Suitable for use in Western Blot, Immunohistochemistry (Paraffin) and Immunocytochemistry. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.