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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A301-039A-T | 10 µl (2 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A301-039A | 100 µl | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Involved in transcriptional activation and repression of select genes by... more
Product information "Anti-SMARCC2/BAF170"
Protein function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. [The UniProt Consortium]
Keywords: | Anti-BAF170, Anti-SMARCC2, Anti-BRG1-associated factor 170, Anti-SWI/SNF complex 170 kDa subunit, Anti-SWI/SNF complex subunit SMARCC2, Anti-SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A301-039A |
Properties
Application: | WB, IP, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse (Expected: rat, bovine, dog, horse, rabbit, pig, panda, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, african elephant, chinese hamster, naked mole rat) |
Immunogen: | synthetic peptide. The epitope recognized by A301-039A-T maps to a region between residue 1164 and the C-terminus (residue 1214) of human SMARCC2/BAF170 using the numbering given in entry NP_003066.2 (GeneID 6601). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K11649 | Matching products |
UniProt ID : | Q8TAQ2 | Matching products |
Gene ID | GeneID 6601 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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