Anti-Smad2 (Ab-220)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABE-35-1644-50	50 µl		-		3 - 11 business days*		574.00€

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Transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase. SMAD2 is a... more

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Product information "Anti-Smad2 (Ab-220)"

Transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase. SMAD2 is a receptor-regulated SMAD (R-SMAD). May act as a tumor suppressor in colorectal carcinoma. Protein function: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [The UniProt Consortium]

Keywords:	Anti-MADH2, Anti-SMAD2, Anti-Smad2, Anti-JV18-1, Anti-hMAD-2, Anti-SMAD 2, Anti-hSMAD2, Anti-MAD homolog 2, Anti-SMAD family member 2, Anti-Mad-related protein 2, Anti-Mothers against DPP homolog 2, Anti-Mothers against decapentaplegic homolog 2, Polyclon
Supplier:	Abeomics
Supplier-Nr:	35-1644-50

Properties

Application:	WB, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Peptide sequence around aa.218~222 (P-E-T-P-P) derived from Human Smad2.
Format:	Purified