Anti-phospho-Smad2 (Thr220)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG51796.50	50 µl		-	-	6 - 14 business days*		436.00€
ARG51796.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and... more

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Product information "Anti-phospho-Smad2 (Thr220)"

Protein function: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [The UniProt Consortium]

Keywords:	Anti-phospho-Smad2, Anti-phospho-MADH2, Anti-phospho-SMAD2, Anti-phospho-SMAD 2, Anti-phospho-hSMAD2, Anti-phospho-JV18-1, Anti-phospho-hMAD-2, Anti-phospho-MAD homolog 2, Anti-phospho-SMAD family member 2, Anti-phospho-Mad-related protein 2
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG51796

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Peptide sequence around phosphorylation site of threonine 220 (P-E-T(p)-P-P) derived from Human Smad2
Format:	Affinity Purified